767334-89-4
767334-89-4
Chemical Structure
AVE1231
Synonym(s): A293
- CAS No.: 767334-89-4
- Formula:C20H27N3O4S
- Molecular Weight:405.51
IUPAC Name: (R)-2-(butylsulfonamido)-N-(1-(6-methoxypyridin-3-yl)propyl)benzamide
InChIKey: BFQMQSIBOHOPCY-QGZVFWFLSA-N
SMILES: O=C(N[C@@H](C1=CC=C(OC)N=C1)CC)C2=CC=CC=C2NS(=O)(CCCC)=O
Biological Activity: AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208)-activated IKACh (IC50=8.4 μM). AVE1231 can be used in the study of arrhythmias and atrial fibrillation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AVE1231 | 98.61% | AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208)-activated IKACh (IC50=8.4 μM). AVE1231 can be used in the study of arrhythmias and atrial fibrillation. | ||||||||||||||||||||
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References
- [1]. Wiedmann F, et al. Identification of the A293 (AVE1231) binding site in the cardiac two-pore-domain potassium channel TASK-1: a common low affinity antiarrhythmic drug binding site[J]. Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, 52(5). [Content Brief]
- [2]. Wirth K J, et al. In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231[J]. Journal of cardiovascular pharmacology, 2007, 49(4): 197-206. [Content Brief]
Keywords
