807-38-5
807-38-5
Chemical Structure
Fluocinolone
- CAS No.: 807-38-5
- Formula:C21H26F2O6
- Molecular Weight:412.42
IUPAC Name: (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChIKey: UUOUOERPONYGOS-CLCRDYEYSA-N
SMILES: F[C@]([C@](C1=CC2=O)(C=C2)C)([C@H](C3)O)[C@](C[C@@H]1F)([H])[C@@](C[C@H]4O)([H])[C@]3([C@](O)4C(CO)=O)C
Biological Activity: Fluocinolone is a potent steroid with highly selective glucocorticoid receptor agonist activity. Fluocinolone stabilizes the blood-retinal barrier by enhancing endothelial tight junctions, inhibiting the VEGF pathway and inflammatory factors. Fluocinolone has high lipophilicity, enabling long-term sustained release in the vitreous. Fluocinolone is used in research related to dermatological diseases, diabetic macular edema, uveitis and oral lichen planus[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fluocinolone | 98.59% | Fluocinolone is a potent steroid with highly selective glucocorticoid receptor agonist activity. Fluocinolone stabilizes the blood-retinal barrier by enhancing endothelial tight junctions, inhibiting the VEGF pathway and inflammatory factors. Fluocinolone has high lipophilicity, enabling long-term sustained release in the vitreous. Fluocinolone is used in research related to dermatological diseases, diabetic macular edema, uveitis and oral lichen planus. | ||||||||||||||||||||
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Fluocinolone (Standard) | ≥98% | Fluocinolone (Standard) is the analytical standard of Fluocinolone (HY-136642). This product is intended for research and analytical applications. Fluocinolone is a potent steroid with highly selective glucocorticoid receptor agonist activity. Fluocinolone stabilizes the blood-retinal barrier by enhancing endothelial tight junctions, inhibiting the VEGF pathway and inflammatory factors. Fluocinolone has high lipophilicity, enabling long-term sustained release in the vitreous. Fluocinolone is used in research related to dermatological diseases, diabetic macular edema, uveitis and oral lichen planus. | ||||||||||||||||||||
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Flumethasone pivalate | 98.17% | Flumethasone pivalate (Flumethasone 21-pivalate) is a glucocorticoid and a topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive actions. Flumethasone pivalate inhibits foreign body granuloma formation. Flumethasone pivalate can be used for the researches of dermatitis, eczema, and psoriasis. | ||||||||||||||||||||
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Diflucortolone | Diflucortolone is a fluorinated corticosteroid with fluorine atoms at the C6 and C9 positions. | |||||||||||||||||||||
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Halobetasol | 99.11% | Halobetasol (Ulobetasol) is a corticosteroid. Halobetasol can be used for research of severe localized psoriasis. | ||||||||||||||||||||
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Flumethasone 21-acetate | Flumethasone 21-acetate (Compound 35) is a type of steroid. Flumethasone 21-acetate has lipophilic properties. | |||||||||||||||||||||
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6β-Hydroxy dexamethasone | 99.03% | 6β-Hydroxy dexamethasone is an active metabolite of the synthetic glucocorticoid Dexamethasone (HY-14648). | ||||||||||||||||||||
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Fluticasone 17β-carboxylic acid | Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid Fluticasone propionate (HY-B0154). | |||||||||||||||||||||
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Diflorasone | 99.84% | Diflorasone is a potent topical anti-inflammatory Corticosteroid. Diflorasone induces vasoconstriction when applied topically. Diflorasone can be used in research related to psoriasis, atopic dermatitis/neurodermatitis. | ||||||||||||||||||||
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Triamcinolone (Standard) | 98.02% | Triamcinolone (Standard) is the analytical standard of Triamcinolone. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Fluticasone | 98.70% | Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells. | ||||||||||||||||||||
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Flumethasone | 99.84% | Flumethasone (Flumetasone) is an orally active, high selective and potent glucocorticoid receptor (GR) agonist. Flumethasone activates GR to inhibit nuclear factor kappa B (NF-κB)-mediated pro-inflammatory cytokine production (TNF-α, IL-1β) and promotes anti-inflammatory gene expression (IL-10), while also regulating metabolic enzyme activity (tyrosine aminotransferase induction). Flumethasone is promising for research of inflammatory diseases, cancer, and endocrine regulation. | ||||||||||||||||||||
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References
- [1]. Aizawa Y, et al. Effects of difluprednate on adrenal cortex and gonadal functions. Folia Pharmacologica Japonica, 1984, 84: 553-561.
- [2]. Buajeeb W, et al. Efficacy of fluocinolone acetonide gel in the treatment of oral lichen planus. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 2000, 89(1): 42-45.
- [3]. Jaffe GJ, et al. Fluocinolone acetonide sustained drug delivery device to treat severe uveitis. Ophthalmology. 2000;107(11):2024-2033. [Content Brief]
- [4]. Veritti D, et al. Fluocinolone acetonide for the treatment of diabetic macular edema. Expert Opinion on Pharmacotherapy, 2017, 18(14): 1507-1516.
