877176-23-3
877176-23-3
Chemical Structure
Aderamastat
Synonym(s): FP-025
- CAS. Nr.: 877176-23-3
- Formula:C21H18N2O4S
- Molecular Weight:394.44
InChIKey: CXEKSVVDMIAMLF-UHFFFAOYSA-N
SMILES: O=C1NC(C(C2=C(SC3=CC=C(C=C3)OCC4=CC(C)=CC=C4)C=CO2)N1)=O
Biological Activity: Aderamastat (FP-025) is an orally active, selective MMP-12 inhibitor. Aderamastat provides protection against house dust mite (HDM)-sensitized allergic asthma. Aderamastat can be used in the research of respiratory diseases, including chronic inflammatory airway diseases and pulmonary fibrosis[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Aderamastat | 98.35% | Aderamastat (FP-025) is an orally active, selective MMP-12 inhibitor. Aderamastat provides protection against house dust mite (HDM)-sensitized allergic asthma. Aderamastat can be used in the research of respiratory diseases, including chronic inflammatory airway diseases and pulmonary fibrosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Abd-Elaziz KS, et al. Validation of a method for the determination of Aderamastat (FP-025) in K2EDTA human plasma by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Sep 15;1245:124244. [Content Brief]
- [2]. Abd-Elaziz K, et al. First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects. Clin Drug Investig. 2021 Jan;41(1):65-76. [Content Brief]
- [3]. Ravanetti L, et al. Efficacy of FP-025: A novel matrix metalloproteinase-12 (MMP-12) inhibitor in murine allergic asthma. Allergy. 2023 Feb;78(2):559-562. [Content Brief]
