MAO-B-IN-33
MAO-B-IN-33 (compound C3) is a potent, reversible and selective monoamine oxidase-B (MAO-B) inhibitor with an IC50 of 0.021 μM and 26.805 μM for MAO-B and MAO-A, respectively. The selectivity of MAO-B-IN-33 is attributed to the steric clash arising from the residue differences between Phe208 (MAO-A) and Ile199 (MAO-B). MAO-B-IN-33 inhibits cerebral MAO-B activity and alleviates MPTP (HY-15608)-induced dopaminergic neuronal loss in the mouse. MAO-B-IN-33 has the potential for Parkinson's disease research.
For research use only. We do not sell to patients.
- CAS No.: 2286257-25-6
- Formula: C18H19FN2O2
- Molecular Weight:314.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MAO-B 0.021 μM (IC50) |
MAO-A 26.805 μM (IC50) |
Chemical Information
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CAS No. 2286257-25-6
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Molecular Weight 314.35
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Formula C18H19FN2O2
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SMILES
NC([C@@H]1CCN1CC2=CC=C(OCC3=CC(F)=CC=C3)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-B-IN-33 Related Classifications
HY-158732 Related Classifications
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