MAO-B-IN-5
MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 µM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD).
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- CAS. Nr.: 849909-77-9
- Formel: C19H21FN2O2
- Molecular Weight:328.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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MAO-B 34.190 μM (IC50) |
MAO-A 0.204 μM (IC50) |
In Vitro
In Vivo
Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats[1].
| Compound | Route | Dose (mg/kg) | Cmax (ng/mL) | AUCt (ng·h/mL) | T1/2 (h) | Vss (h) | Cl (mL/min/kg) | F (%) |
| D0 | iv | 1 | 809 | 347 | 0.37 | 1.11 | 47.1 | / |
| po | 5 | 163 | 284 | 1.27 | / | / | 16.3 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SD rats[1]
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Dosage:1, 5 mg/kg
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Administration:1 mg/kg, i.v.; 5 mg/kg, p.o.
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Result:Showed oral bioavailability in rats (F=16.3%).
Chemical Information
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CAS. Nr. 849909-77-9
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Molecular Weight 328.38
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Formel C19H21FN2O2
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SMILES
NC([C@@H]1CCCN1CC2=CC=C(C=C2)OCC3=CC(F)=CC=C3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MAO-B-IN-5 Related Classifications
HY-115986 Related Classifications
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