MAO-B-IN-5
MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 µM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD).
For research use only. We do not sell to patients.
- CAS No.: 849909-77-9
- Formula: C19H21FN2O2
- Molecular Weight:328.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MAO-B 34.190 μM (IC50) |
MAO-A 0.204 μM (IC50) |
Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats[1].
| Compound | Route | Dose (mg/kg) | Cmax (ng/mL) | AUCt (ng·h/mL) | T1/2 (h) | Vss (h) | Cl (mL/min/kg) | F (%) |
| D0 | iv | 1 | 809 | 347 | 0.37 | 1.11 | 47.1 | / |
| po | 5 | 163 | 284 | 1.27 | / | / | 16.3 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SD rats[1]
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Dosage:1, 5 mg/kg
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Administration:1 mg/kg, i.v.; 5 mg/kg, p.o.
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Result:Showed oral bioavailability in rats (F=16.3%).
Chemical Information
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CAS No. 849909-77-9
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Molecular Weight 328.38
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Formula C19H21FN2O2
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SMILES
NC([C@@H]1CCCN1CC2=CC=C(C=C2)OCC3=CC(F)=CC=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-B-IN-5 Related Classifications
HY-115986 Related Classifications
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