MAO-B-IN-5
MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 µM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 849909-77-9
- 分子式: C19H21FN2O2
- 分子量:328.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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MAO-B 34.190 μM (IC50) |
MAO-A 0.204 μM (IC50) |
体外実験
体内実験
Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats[1].
| Compound | Route | Dose (mg/kg) | Cmax (ng/mL) | AUCt (ng·h/mL) | T1/2 (h) | Vss (h) | Cl (mL/min/kg) | F (%) |
| D0 | iv | 1 | 809 | 347 | 0.37 | 1.11 | 47.1 | / |
| po | 5 | 163 | 284 | 1.27 | / | / | 16.3 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SD rats[1]
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Dosage:1, 5 mg/kg
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Administration:1 mg/kg, i.v.; 5 mg/kg, p.o.
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Result:Showed oral bioavailability in rats (F=16.3%).
化学情報
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CAS 番号 849909-77-9
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分子量 328.38
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分子式 C19H21FN2O2
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SMILES
NC([C@@H]1CCCN1CC2=CC=C(C=C2)OCC3=CC(F)=CC=C3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MAO-B-IN-5 関連分類
HY-115986 関連分類
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