884-33-3
884-33-3
Chemical Structure
2-Benzylsuccinic acid
Synonym(s): DL-Benzylsuccinic acid
- CAS No.: 884-33-3
- Formula:C11H12O4
- Molecular Weight:208.21
IUPAC Name: 2-benzylsuccinic acid
InChIKey: GTOFKXZQQDSVFH-UHFFFAOYSA-N
SMILES: O=C(O)C(CC1=CC=CC=C1)CC(O)=O
Biological Activity: 2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an orally active carboxypeptidase A and Nna1 inhibitor. 2-Benzylsuccinic acid reduces cold hyperalgesia. 2-Benzylsuccinic acid can be used for the researches of neuropathic pain, non-alcoholic steatohepatitis[1][2][3][4][5].
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2-Benzylsuccinic acid | 99.83% | 2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an orally active carboxypeptidase A and Nna1 inhibitor. 2-Benzylsuccinic acid reduces cold hyperalgesia. 2-Benzylsuccinic acid can be used for the researches of neuropathic pain, non-alcoholic steatohepatitis. | ||||||||||||||||||||
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2-Benzylsuccinic acid (Standard) | ≥98% | 2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an orally active carboxypeptidase A and Nna1 inhibitor. 2-Benzylsuccinic acid reduces cold hyperalgesia. 2-Benzylsuccinic acid can be used for the researches of neuropathic pain, non-alcoholic steatohepatitis. | ||||||||||||||||||||
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References
- [1]. Han MS, et al. A novel strategy for designing irreversible inhibitors of metalloproteases: acetals as latent electrophiles that interact with catalytic nucleophile at the active site. Org Lett. 2000 Oct 5;2(20):3149-52. [Content Brief]
- [2]. Wang R, et al. Identification of 2-PMPA as a novel inhibitor of cytosolic carboxypeptidases. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1393-1399. [Content Brief]
- [3]. Duan J, et al. Therapeutic targeting of hepatic ACSL4 ameliorates NASH in mice. Hepatology. 2022 Jan;75(1):140-153. [Content Brief]
- [4]. Kühlein HN, et al. Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain. PLoS One. 2011 Apr 29;6(4):e19270. [Content Brief]
- [5]. Mark P. Wentland, et al. 96-Well Plate Colorimetric Assay for Ki Determination of (+/-)-2-Benzylsuccinic Acid, an Inhibitor of Carboxypeptidase A: A Laboratory Experiment in Drug Discovery. J Chem Educ. 2004 Mar 1, 81 (3):398.
