D-(+)-Phenyllactic acid
Based on 1 Customer Validation
D-(+)-Phenyllactic acid is an anti-bacterial agent, excreted by Geotrichum candidum, inhibits a range of Gram-positive from humans and foodstuffs and Gram-negative bacteria found in humans.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 7326-19-4
- Formula: C9H10O3
- Molecular Weight:166.18
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Microbial Metabolite |
D-(+)-Phenyllactic acid inhibits the interaction between Mcl-1 and Bim with an IC50 of 0.161 μM[2].
D-(+)-Phenyllactic acid inhibits the cell viability of SKBR-3 with an EC50 of 112.69 nM[2].
D-(+)-Phenyllactic acid (5-20 mg/mL, 27 h) exhibits broad-spectrum antibacterial effect, inhibits L. monocytogenes, S. aureus, E. faecalis and K. oxytoca[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SKBR-3
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Concentration:
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Incubation Time:72 h
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Result:Inhibited the cell viability of SKBR-3.
Chemical Information
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CAS No. 7326-19-4
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Appearance Solid
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Molecular Weight 166.18
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Formula C9H10O3
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Color White to off-white
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SMILES
O=C(O)[C@H](O)CC1=CC=CC=C1
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Synonyms
D-3-Phenyllactic acid
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (601.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (30.09 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Dieuleveux V, et al. Antimicrobial spectrum and target site of D-3-phenyllactic acid. Int J Food Microbiol. 1998 Apr 14;40(3):177-83. [Content Brief]
[2]. Chu H, et al., Mcl-1 inhibitors. WO2019222112
[3]. Dieuleveux V, et al., Antimicrobial spectrum and target site of D-3-phenyllactic acid. Int J Food Microbiol. 1998 Apr 14;40(3):177-83. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.0177 mL | 30.0886 mL | 60.1772 mL | 150.4429 mL |
| 5 mM | 1.2035 mL | 6.0177 mL | 12.0354 mL | 30.0886 mL | |
| 10 mM | 0.6018 mL | 3.0089 mL | 6.0177 mL | 15.0443 mL | |
| 15 mM | 0.4012 mL | 2.0059 mL | 4.0118 mL | 10.0295 mL | |
| 20 mM | 0.3009 mL | 1.5044 mL | 3.0089 mL | 7.5221 mL | |
| 25 mM | 0.2407 mL | 1.2035 mL | 2.4071 mL | 6.0177 mL | |
| 30 mM | 0.2006 mL | 1.0030 mL | 2.0059 mL | 5.0148 mL | |
| DMSO | 40 mM | 0.1504 mL | 0.7522 mL | 1.5044 mL | 3.7611 mL |
| 50 mM | 0.1204 mL | 0.6018 mL | 1.2035 mL | 3.0089 mL | |
| 60 mM | 0.1003 mL | 0.5015 mL | 1.0030 mL | 2.5074 mL | |
| 80 mM | 0.0752 mL | 0.3761 mL | 0.7522 mL | 1.8805 mL | |
| 100 mM | 0.0602 mL | 0.3009 mL | 0.6018 mL | 1.5044 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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