88909-96-0
Chemical Structure
Virstatin
- CAS No.: 88909-96-0
- Formula:C16H13NO4
- Molecular Weight:283.28
IUPAC Name: 4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butanoic acid
InChIKey: ZHXRDXTYPCPBTI-UHFFFAOYSA-N
SMILES: O=C(N(C1=O)CCCC(O)=O)C2=CC=CC3=CC=CC1=C23
Biological Activity: Virstatin is an orally effective Vibrio cholerae virulence inhibitor. Virstatin blocks the expression of downstream virulence genes, such as cholera toxin (ctx) and toxin-coregulated pilus (tcpA), at the post-transcriptional level by inhibiting the dimerization of the transcriptional activator ToxT. Virstatin inhibits Vibrio cholerae-induced expression of COX-2 and iNOS, and exerts bactericidal effects at high concentrations. Virstatin can be used for research on cholera[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Virstatin | 98.00% | Virstatin is an orally effective Vibrio cholerae virulence inhibitor. Virstatin blocks the expression of downstream virulence genes, such as cholera toxin (ctx) and toxin-coregulated pilus (tcpA), at the post-transcriptional level by inhibiting the dimerization of the transcriptional activator ToxT. Virstatin inhibits Vibrio cholerae-induced expression of COX-2 and iNOS, and exerts bactericidal effects at high concentrations. Virstatin can be used for research on cholera. | ||||||||||||||||||||
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References
- [1]. Hung DT, et al. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science. 2005 Oct 28;310(5748):670-4.
- [2]. Satitsri S, et al. Pathophysiological mechanisms of diarrhea caused by the Vibrio cholerae O1 El Tor variant: an in vivo study in mice. Virulence. 2016 Oct 02;7(7):789-805.
- [3]. Woodbrey AK, et al. A Modified ToxT Inhibitor Reduces Vibrio cholerae Virulence in Vivo. Biochemistry. 2018 Sep 25;57(38):5609-5615.
- [4]. Shakhnovich EA, et al. Molecular mechanisms of virstatin resistance by non-O1/non-O139 strains of Vibrio cholerae. Molecular microbiology. 2007 Dec;66(6):1331-41.
- [5]. Lee D, et al. Variations in the antivirulence effects of fatty acids and virstatin against Vibrio cholerae strains. Journal of Microbiology and Biotechnology. 2024 Jul 19;34(9):1757.
- [6]. Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science. 2005 Oct 28;310(5748):670-4.
