90-89-1
90-89-1
Chemical Structure
Diethylcarbamazine
- CAS No.: 90-89-1
- Formula:C10H21N3O
- Molecular Weight:199.29
IUPAC Name: N,N-diethyl-4-methylpiperazine-1-carboxamide
InChIKey: RCKMWOKWVGPNJF-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C)CC1)N(CC)CC
Biological Activity: Diethylcarbamazine is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine reduces serum levels of leptin, TNF-α, IL-6, MCP-1, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine can be used for the researches of bronchial asthma, insulin resistance and infection[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Diethylcarbamazine | 99.86% | Diethylcarbamazine is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine reduces serum levels of leptin, TNF-α, IL-6, MCP-1, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine can be used for the researches of bronchial asthma, insulin resistance and infection. | ||||||||||||||||||||
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Diethylcarbamazine (Standard) | ≥98% | Diethylcarbamazine (Standard) is the analytical standard of Diethylcarbamazine (HY-12642A). This product is intended for research and analytical applications. Diethylcarbamazine is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine reduces serum levels of leptin, TNF-α, IL-6, MCP-1, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine can be used for the researches of bronchial asthma, insulin resistance and infection. | ||||||||||||||||||||
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1,1-Dimethyl-4-acetylpiperazinium iodide | 1,1-Dimethyl-4-acetylpiperazinium iodide is an agonist for nicotinic acetylcholine receptor (nAChR) that open ion channels and causes cell membrane depolarization. | |||||||||||||||||||||
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1-(3-Aminopropyl)-4-methylpiperazine | ≥98.0% | 1-(3-Aminopropyl)-4-methylpiperazine is a capping agent. The 1-(3-Aminopropyl)-4-methylpiperazine-capped Poly (β-amino ester) (PBAE) poly (1,4-butanediol diacrylate-co-4-amino-1-butanol) undergoes electrostatic interactions with anionic molecules such as DNA and exhibits low cytotoxicity. The 1-(3-Aminopropyl)-4-methylpiperazine-capped Poly (1,4-butanediol diacrylate-co-4-amino-1-butanol) PBAE effectively delivers nucleic acids in various systems. | ||||||||||||||||||||
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2,2'-Piperazine-1,4-diyldiethanamine | 96.00% | 2,2'-(Piperazine-1,4-diyl)diethanamine is a piperazine with two N-ethanamine groups. This type of molecule may be used to build drug molecules or design novel ionizable aminolipid head groups for lipid nanoparticles. | ||||||||||||||||||||
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N,N-Diethylacetamide | N,N-Diethylacetamide is a polar solvent widely used in film and fiber manufacturing, as well as in laboratories as a carrier for water-insoluble chemicals. N,N-Diethylacetamide exerts potent anti-inflammatory effects by inhibiting the NF-κB pathway, suppressing the expression of NO and iNOS, and downregulating key inflammatory cytokines such as TNF-α and IL-6, without affecting the MAPK pathway. N,N-Diethylacetamide can be used to study inflammatory preterm birth. | |||||||||||||||||||||
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1,4,7-Trimethyl-1,4,7-triazonane | 98.27% | 1,4,7-Trimethyl-1,4,7-triazonane, also known as TMT or trimethylenetris(aziridine), is a cyclic organic compound. TMT is commonly used as a crosslinking agent and a precursor for polymer and resin synthesis. In addition, it is used as a stabilizer in the production of polyurethane foam and as a curing agent for epoxy resins. Due to its high reactivity and stability, TMT is considered to be a versatile and efficient reagent in various applications. | ||||||||||||||||||||
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N,N'-Diacryloylpiperazine | 98.0% | N,N'-Diacryloylpiperazine can be used to synthesize bioconjugates and other compounds, and can also be used in the fields of medicine and biotechnology. N,N'-Diacryloylpiperazine is a biomaterial or organic compound that can be used for life science research. | ||||||||||||||||||||
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2-(4-(2-Hydroxyethyl)piperazin-1-yl)acetic acid | 2-(4-(2-Hydroxyethyl)piperazin-1-yl)acetic acid is a PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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1-Methyl-4-nitrosopiperazine | 99.33% | 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics. | ||||||||||||||||||||
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1-(2-Chloro-acetyl)-piperazine | 1-(2-Chloro-acetyl)-piperazine is a PROTAC linker. 1-(2-Chloro-acetyl)-piperazine can be used to synthesize PROTAC TEAD1/IAP degrader-2 (HY-181537) . | |||||||||||||||||||||
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References
- [1]. Abdul-Razek N, et al. Enhancement of Anti-allergic Effect of Diethylcarbamazine Citrate in Asthmatic Mouse Model: Testing of Anti-drug Antibodies and Quercetin. Iran J Allergy Asthma Immunol. 2020;19(4):373-385. Published 2020 Aug 25. [Content Brief]
- [2]. Abdel-Latif M, et al. Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. Int Immunopharmacol. 2015;29(2):607-612. [Content Brief]
- [3]. García-Hernández M, et al. Immunomodulatory effect of diethylcarbamazine in mice infected with Nocardia brasiliensis. Int Immunopharmacol. 2014;23(1):113-120. [Content Brief]
