93952-19-3
93952-19-3
Chemical Structure
p,p'-DDE-d8
Synonym(s): 4,4'-DDE-d8;p,p'-Dichlorodiphenyldichloroethylene-d8
- CAS No.: 93952-19-3
- Formula:C14D8Cl4
- Molecular Weight:326.07
IUPAC Name: isophthalic-2,4,5,6-d4 acid
InChIKey: UCNVFOCBFJOQAL-PGRXLJNUSA-N
SMILES: Cl/C(Cl)=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)/C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl
Biological Activity: p,p'-DDE-d8 is the deuterium labeled p,p'-DDE[1]. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].
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p,p'-DDE-d8 | 99% | p,p'-DDE-d8 is the deuterium labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM. | ||||||||||||||||||||
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p,p'-DDE (Standard) | ≥98% | p,p'-DDE (Standard) is the analytical standard of p,p'-DDE. This product is intended for research and analytical applications. p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women. | ||||||||||||||||||||
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p,p'-DDE-13C12 | p,p'-DDE-13C12 is 13C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM. | |||||||||||||||||||||
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p,p'-DDE | 99.91% | p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.82
HY-121779o,p'-DDE -
Similarity Score 0.81
HY-W0119184,4'-Dichlorobenzophenone -
Similarity Score 0.73
HY-B1984p,p'-DDD -
Similarity Score 0.73
HY-W750297p,p'-DDD-13C12 -
Similarity Score 0.73
HY-W012217R(4-Chlorophenyl)(4-hydroxyphenyl)methanone (Standard) -
Similarity Score 0.72
![1-Chloro-4-[2-chloro-1-(4-chlorophenyl)ethyl]benzene Chemical Structure](//file.medchemexpress.com/product_pic/hy-w078592.gif)
HY-W0785921-Chloro-4-[2-chloro-1-(4-chlorophenyl)ethyl]benzene -
Similarity Score 0.71
HY-130498DDOH -
Similarity Score 0.71
HY-122551Chlorfenethol -
Similarity Score 0.70
HY-W0119172,4'-Dichlorobenzophenone -
Explore the MedChemAI to find more analogs
![1-Chloro-4-[2-chloro-1-(4-chlorophenyl)ethyl]benzene Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w078592.gif)
References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Kelce WR, et al. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375(6532):581-585. [Content Brief]
