2. PROTAC Apoptosis
  3. Ligands for E3 Ligase Molecular Glues Apoptosis
  4. Eragidomide

Eragidomide  (Synonyms: CC-90009)

製品番号: HY-130800 純度: 99.93%
COA 取扱説明書 Technical Support

Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation.

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CAS 番号 : 1860875-51-9

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 101 在庫あり
Solution
10 mM * 1 mL in DMSO USD 101 在庫あり
Solid
5 mg $99 在庫あり
10 mg $176 在庫あり
25 mg $363 在庫あり
50 mg $605 在庫あり
100 mg $800 在庫あり
250 mg $1200 在庫あり
500 mg $1800 在庫あり
1 g $2700 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

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カスタマーレビュー

Based on 7 publication(s) in Google Scholar

Eragidomide 関連抗体

Top Publications Citing Use of Products

    Eragidomide purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Nov 21:10.1158/0008-5472.CAN-24-3753.  [Abstract]

    After treating MOLM-13 cells with DMSO or a specified concentration of CC-90009 for 24 hours, Western blot analysis was performed on the GSPT1 protein level in the cells.

    Eragidomide purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Sep;39(9):2163-2173.  [Abstract]

    Cell viability was determined in the indicated cell lines cultured with CA-4948 (10 µM) or vehicle for 2 weeks and then treated with CC-90009 or vehicle (n = 4).

    Eragidomide purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2023 Mar;19(3):323-333.  [Abstract]

    Dose-resolved, normalized viability after 3 d treatment with CC-90009 in RKO CRBN-/- cells with over-expression of CRBNWT, CRBNE377K, CRBNN351D and CRBNH397D.

    Eragidomide purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2023 Mar;19(3):323-333.  [Abstract]

    Protein levels in RKO CRBN-/- cells with over-expression of CRBNWT, CRBNN351D, CRBNH397D or CRBNH57D treated with DMSO, CC-90009 (50 nM, 6 h), dBET6 (15 nM, 2 h), dBET57 (240 nM, 2 h) or THAL-SNS-032 (200 nM, 2 h).

    Eragidomide purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2023 Mar;19(3):323-333.  [Abstract]

    Depiction of clonogenic assays via crystal violet staining. Cells were treated for 10 days at EC90 of the degrader (30 nM dBET6, 60 nM CC-90009).

    Ligands for E3 Ligase アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation[1][2].

    IC50 & Target[1]

    Cereblon

     

    Cellular Effect
    Cell Line Type Value Description References
    Bone marrow cell EC50
    6 nM
    Compound: 16; CC-90009
    Antiproliferative activity in bone marrow cells derived from AML patients assessed as cell growth inhibition
    Antiproliferative activity in bone marrow cells derived from AML patients assessed as cell growth inhibition
    		[PMID: 33591756]
    K562 IC50
    > 40 μM
    Compound: CC-90009
    Antiproliferative activity against human K562 cells incubated for 48 hrs by MTS assay
    Antiproliferative activity against human K562 cells incubated for 48 hrs by MTS assay
    		[PMID: 38795517]
    MV4-11 EC50
    0.062 μM
    Compound: 5; CC-90009
    Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 3 days by CellTiter-Glo assay
    Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 3 days by CellTiter-Glo assay
    		[PMID: 34042448]
    OCI-AML2 IC50
    0.01 μM
    Compound: CC-90009
    Antiproliferative activity against human OCI-AML2 cells incubated for 48 hrs by MTS assay
    Antiproliferative activity against human OCI-AML2 cells incubated for 48 hrs by MTS assay
    		[PMID: 38795517]
    RS4-11 IC50
    0.1 nM
    Compound: CC-90009
    Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
    Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
    		[PMID: 37390512]
    U-266 IC50
    0.04 μM
    Compound: CC-90009
    Antiproliferative activity against human U-266 cells incubated for 48 hrs by MTS assay
    Antiproliferative activity against human U-266 cells incubated for 48 hrs by MTS assay
    		[PMID: 38795517]
    U-937 IC50
    < 0.032 μM
    Compound: CC-90009
    Antiproliferative activity against human U-937 cells incubated for 48 hrs by MTS assay
    Antiproliferative activity against human U-937 cells incubated for 48 hrs by MTS assay
    		[PMID: 38795517]
    体外実験

    Depletion of GSPT1 by Eragidomide rapidly induces acute myeloid leukemia (AML) apoptosis, reducing leukemia engraftment and leukemia stem cells (LSCs) in large-scale primary patient xenografting of 35 independent AML samples. Eragidomide activity is mediated by multiple layers of signaling networks and pathways within AML blasts and LSCs[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Eragidomide 関連抗体
    臨床実験
    分子量

    461.85

    分子式

    C22H18ClF2N3O4
    CAS 番号
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)C(F)(F)C4=CC=C(Cl)C=C4
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (216.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1652 mL 10.8260 mL 21.6521 mL
    5 mM 0.4330 mL 2.1652 mL 4.3304 mL
    10 mM 0.2165 mL 1.0826 mL 2.1652 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.93%

    COA (246 KB) HNMR (295 KB) RP-HPLC (246 KB) MS (180 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1652 mL 10.8260 mL 21.6521 mL 54.1301 mL
    5 mM 0.4330 mL 2.1652 mL 4.3304 mL 10.8260 mL
    10 mM 0.2165 mL 1.0826 mL 2.1652 mL 5.4130 mL
    15 mM 0.1443 mL 0.7217 mL 1.4435 mL 3.6087 mL
    20 mM 0.1083 mL 0.5413 mL 1.0826 mL 2.7065 mL
    25 mM 0.0866 mL 0.4330 mL 0.8661 mL 2.1652 mL
    30 mM 0.0722 mL 0.3609 mL 0.7217 mL 1.8043 mL
    40 mM 0.0541 mL 0.2707 mL 0.5413 mL 1.3533 mL
    50 mM 0.0433 mL 0.2165 mL 0.4330 mL 1.0826 mL
    60 mM 0.0361 mL 0.1804 mL 0.3609 mL 0.9022 mL
    80 mM 0.0271 mL 0.1353 mL 0.2707 mL 0.6766 mL
    100 mM 0.0217 mL 0.1083 mL 0.2165 mL 0.5413 mL
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    Eragidomide Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Eragidomide1860875-51-9CC-90009CC90009CC 90009Ligands for E3 LigaseMolecular GluesApoptosisE3 ligase-recruiting MoietyCRBNIRF4c-mycanti-cancerdegradationproteasome-mediatedIKZF1IKZF3T-lymphocytesInhibitorinhibitorinhibit

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    製品名:
    Eragidomide
    製品番号:
    HY-130800
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