CGRP antagonist-9
CGRP antagonist-9 is a CGRP receptor antagonist with an IC50 of 25 nM. It regulates the cAMP signaling pathway and can be used in migraine-related studies.
For research use only. We do not sell to patients.
- CAS No.: 1610413-84-7
- Formula: C40H49N9O4S
- Molecular Weight:751.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-N-MC | EC50 |
96 nM
Compound: 7
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Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay
Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay
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[PMID: 24794104] |
CGRP antagonist-9 (Compound 7) antagonizes αCGRP-induced cAMP production in SK-N-MC cells with an EC50 of 96 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1610413-84-7
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Molecular Weight 751.94
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Formula C40H49N9O4S
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SMILES
O=C1N(C2CCN(CC2)C(N[C@@H](C(N[C@@H](CCCCN)C(N3CCN(C4=CC=NC=C4)CC3)=O)=O)CC5=CC6=CC=CC=C6S5)=O)CC7=CC=CC=C7N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGRP antagonist-9 Related Classifications
HY-183181 Related Classifications
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