23-Oxa-OSW-1
23-Oxa-OSW-1 (SBF-1), a derivative of OSW 1 (HY-101213), is a potent osterol-binding protein (OSBP) inhibitor. 23-Oxa-OSW-1 has antitumor activity.
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- CAS. Nr.: 790224-37-2
- Formel: C54H82O16
- Molecular Weight:987.22
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.071 μM
Compound: 1, 23-oxa-OSW
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Antiproliferative activity against human HeLa cells
Antiproliferative activity against human HeLa cells
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[PMID: 17127060] |
| Jurkat | IC50 |
0.015 μM
Compound: 1, 23-oxa-OSW
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Antiproliferative activity against human Jurkat cells
Antiproliferative activity against human Jurkat cells
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[PMID: 17127060] |
| RKO | IC50 |
0.0007 μM
Compound: 1, 23-oxa-OSW
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Antiproliferative activity against human RKO cells
Antiproliferative activity against human RKO cells
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[PMID: 17127060] |
| RKO | IC50 |
0.7 nM
Compound: 1, 23-oxa-OSW
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Antiproliferative activity against human RKO cells
Antiproliferative activity against human RKO cells
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[PMID: 17127060] |
In Vitro
23-Oxa-OSW-1 has antitumor activites with IC50 values of 0.0022, 0.012, and 0.094 μM in HeLa, Jurkat T, and MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 790224-37-2
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Molecular Weight 987.22
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Formel C54H82O16
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SMILES
C[C@@]1([C@](O)2[C@H](C)C(OCCCCCCCCCCCC)=O)[C@](C[C@@H]2O[C@H](OC[C@@H]3O)[C@@H]([C@H]3O[C@H](OC[C@H]4O)[C@@H]([C@H]4O)OC(C(C=C5)=CC=C5OC)=O)OC(C)=O)([H])[C@@](CC=C(C6)[C@@]7(CC[C@@H]6O)C)([H])[C@]7([H])CC1
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Synonyms
SBF-1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Reinheit & Dokumentation
Verweise
[1]. Shi B, et, al. OSW saponins: facile synthesis toward a new type of structures with potent antitumor activities. J Org Chem. 2005 Dec 9;70(25):10354-67. [Content Brief]
[2]. Tan JX, et, al. A phosphoinositide signalling pathway mediates rapid lysosomal repair. Nature. 2022 Sep;609(7928):815-821. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
23-Oxa-OSW-1 Related Classifications
HY-148391 Related Classifications
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