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Art. -Nr.: HY-181724

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501A054

501A054 is an autophagy activator. 501A054 induces autophagy-dependent cell death via autophagy activation. 501A054 can be used in studies on autophagy regulation such as cervical cancer.

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CAS. Nr.: 3080980-06-6
Formel: C₂₇H₃₅N₃O₂
Molecular Weight:433.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

501A054 Chemical Structure

CAS. Nr.: 3080980-06-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

501A054 is an autophagy activator. 501A054 induces autophagy-dependent cell death via autophagy activation. 501A054 can be used in studies on autophagy regulation such as cervical cancer^[1].

In Vitro

501A054 (Compound 3o) (4 h) potently activates autophagy in HeLa cells stably expressing eGFP-LC3, with an EC₅₀ of 2.3 μM^[1].
501A054 (16-32 μM; 4-24 h) induces autophagy-dependent perinuclear vacuole formation in eGFP-LC3 HeLa cells after treatment with 16 μM for 4 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

eGFP-LC3 HeLa cells, ATG9A KO HeLa cells
Concentration:

16 μM (eGFP-LC3 HeLa cells); 32 μM (ATG9A KO HeLa cells)
Incubation Time:

4 h (eGFP-LC3 HeLa cells); 24 h (ATG9A KO HeLa cells)
Result:

Induced perinuclear vacuole formation in eGFP-LC3 HeLa cells at 16 μM after 4 h.
Showed no vacuole formation in ATG9A KO HeLa cells at 32 μM after 24 h.

Chemical Information

CAS. Nr. 3080980-06-6
Molecular Weight 433.59
Formel C₂₇H₃₅N₃O₂
SMILES

OCC1CN(CCC2=CC=CC=C2)CC31CCN(CC4=CNC5=C4C=C(OC)C=C5)CC3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Andrew Dobria, et al. Structure-Activity Relationship Studies Enable Optimization of a
Small-Molecule Autophagy Activator and Evaluation of Effects on Cell Death Pathways.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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