8-Aminoadenine
Based on 1 Customer Validation
8-Aminoadenine is an adenine receptor 1 (rAde1R) inhibitor with a Ki of 6.51 μM in rat and 0.0341 μM in human. 8-Aminoadenine inhibits isoprenaline-induced cAMP accumulation and adenine uptake in astrocytoma cells expressing rAde1R. 8-Aminoadenine serves as a lead structure for the development of adenine receptor ligands to elucidate the functions of the adenine receptor family.
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- Reinheit: 98.34%
- CAS. Nr.: 28128-33-8
- Formel: C5H6N6
- Molecular Weight:150.14
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
Ki：6.51 μM (adenine receptor)[1].
8-Aminoadenine (Compound 33) binds to rat cerebral cortex membrane preparations (rAde1R) with a Ki value of 6.51 μM[1].
8-Aminoadenine binds to HEK293 cell membrane preparations with a Ki value of 0.0341 μM[1].
8-Aminoadenine (500 μM; 10 min) inhibits isoprenaline (HY-B0468)-induced cAMP accumulation in 1321N1 astrocytoma cells[1].
8-Aminoadenine (100 μM; 1 min) potently inhibits [3H] adenine uptake in 1321N1 astrocytoma cells stably expressing rAde1R[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 28128-33-8
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Appearance Solid
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Molecular Weight 150.14
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Formel C5H6N6
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Color Brown to reddish brown
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SMILES
NC1=C2N=C(N)NC2=NC=N1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
1 M HCl : 0.5 mg/mL (3.33 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1 M HCl | 1 mM | 6.6605 mL | 33.3023 mL | 66.6045 mL | 166.5113 mL |
8-Aminoadenine Related Classifications
HY-103172 Related Classifications
Powered by Bioz
- 8-Aminoadenine
- 28128-33-8
- P2Y Receptor
- rat brain cortical membrane preparations
- adenine receptor family
- rAde1R
- human embryonic kidney (HEK293) cell membrane preparations
- 1321N1 astrocytoma cells
- human adenine binding site
- rat adenine receptor 1
- adenine receptor ligands
- astrocytoma cells
- Inhibitor
- inhibitor
- inhibit