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Art. -Nr.: HY-112772A

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98N12-5

Name: 98N12-5
Brand: MedChemExpress
SKU: HY-112772A
Price: 120.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

98N12-5 is a lipid delivery material that assembles to form lipid nanoparticles and mediates the intracellular delivery of siRNA to hepatocytes. 98N12-5 is used in RNA interference-related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 98.0%
CAS. Nr.: 917572-74-8
Formel: C₈₁H₁₆₃N₉O₅
Molecular Weight:1343.22

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

98N12-5 Chemical Structure

CAS. Nr.: 917572-74-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

98N12-5 is a lipid delivery material that assembles to form lipid nanoparticles and mediates the intracellular delivery of siRNA to hepatocytes. 98N12-5 is used in RNA interference-related research^[1]^[2].

In Vivo

98N12‑5‑based LNPs accumulate in the mouse liver, and these LNPs encapsulating anti‑FVII, anti‑PCSK9, or anti‑ApoB siRNA achieve target gene knockdown in in vivo models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

RNA interference technology

Chemical Information

CAS. Nr. 917572-74-8
Appearance Solid
Molecular Weight 1343.22
Formel C₈₁H₁₆₃N₉O₅
Color Off-white to light yellow
SMILES

CCCCCCCCCCCCNC(CCN(CCN(CCC(NCCCCCCCCCCCC)=O)CCC(NCCCCCCCCCCCC)=O)CCNCCN(CCC(NCCCCCCCCCCCC)=O)CCC(NCCCCCCCCCCCC)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Adv Sci (Weinh)

Localized NF-κB Inhibition Reduces Lipid Nanoparticle-Associated Inflammation. [Abstract]

2026 Mar 24:e17931. PMID: 41875360

Lösungsmittel & Löslichkeit

In Vitro:

THF : 50 mg/mL (37.22 mM; Need ultrasonic)

DMSO : 50 mg/mL (37.22 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (37.22 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.7445 mL

3.7224 mL

7.4448 mL

5 mM

0.1489 mL

0.7445 mL

1.4890 mL

10 mM

0.0744 mL

0.3722 mL

0.7445 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang Y, et al. Lipids and Lipid Derivatives for RNA Delivery. Chemical reviews. 2021 Oct 27;121(20):12181-12277.

[2]. Goldberg MS. Screening, synthesis, and applications of "lipidoids", a novel class of molecules developed for the delivery of RNAi therapeutics. Massachusetts Institute of Technology. 2008.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
THF / DMSO / Ethanol	1 mM	0.7445 mL	3.7224 mL	7.4448 mL	18.6120 mL
	5 mM	0.1489 mL	0.7445 mL	1.4890 mL	3.7224 mL
	10 mM	0.0744 mL	0.3722 mL	0.7445 mL	1.8612 mL
	15 mM	0.0496 mL	0.2482 mL	0.4963 mL	1.2408 mL
	20 mM	0.0372 mL	0.1861 mL	0.3722 mL	0.9306 mL
	25 mM	0.0298 mL	0.1489 mL	0.2978 mL	0.7445 mL
	30 mM	0.0248 mL	0.1241 mL	0.2482 mL	0.6204 mL

Bioz

Keywords

98N12-5

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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98N12-5

Publications Citing Use of MedChemExpress (MCE) 98N12-5