Art. -Nr.: HY-19354

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Aglafoline

(Synonyms: Aglafolin; Rocaglamide U; (-)-Methyl rocaglate)

1 Cited Publications

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Aglafoline inhibits PAF-induced platelet aggregation, with an IC50 value of 50 μM.

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Reinheit: 98.20%
CAS. Nr.: 143901-35-3
Formel: C₂₈H₂₈O₈
Molecular Weight:492.52

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Aglafoline Chemical Structure

CAS. Nr.: 143901-35-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Aglafoline inhibits PAF-induced platelet aggregation, with an IC50 value of 50 μM.

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.001 μg/mL Compound: 1a	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 9214732]
Col2	ED₅₀	243 nM Compound: 2	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 15043407]
HCT-8	IC₅₀	0.005 μg/mL Compound: 1a	Cytotoxicity against human HCT8 cells Cytotoxicity against human HCT8 cells	[PMID: 9214732]
HepG2	CC₅₀	65.3 nM Compound: 11bc	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 38127656]
HepG2	CC₅₀	689.8 nM Compound: 11bc	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 38127656]
HT-29	ED₅₀	0.012 μM Compound: 10	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 23301897]
HUVEC	ED₅₀	203 nM Compound: 2	Cytotoxicity against HUVEC Cytotoxicity against HUVEC	[PMID: 15043407]
KB	ED₅₀	142 nM Compound: 2	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 15043407]
KB	IC₅₀	0.001 μg/mL Compound: 1a	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 9214732]
LNCaP	ED₅₀	325 nM Compound: 2	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 15043407]
Lu1	ED₅₀	163 nM Compound: 2	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 15043407]
MDA-MB-231	EC₅₀	10 nM Compound: 47	Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay	[PMID: 23025805]
MDA-MB-231	EC₅₀	16 nM Compound: 47	Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay	[PMID: 23025805]
MDA-MB-231	EC₅₀	90 nM Compound: 47	Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay	[PMID: 23025805]
P388	IC₅₀	0.002 μg/mL Compound: 1a	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 9214732]
RPMI-7951	IC₅₀	0.001 μg/mL Compound: 1a	Cytotoxicity against human RPMI7951 cells Cytotoxicity against human RPMI7951 cells	[PMID: 9214732]
TE-671	IC₅₀	0.001 μg/mL Compound: 1a	Cytotoxicity against human TE671 cells Cytotoxicity against human TE671 cells	[PMID: 9214732]
TERT-RPE1	ED₅₀	183 nM Compound: 2	Cytotoxicity against human telomerase reverse transcriptase expressing human RPE1 cells Cytotoxicity against human telomerase reverse transcriptase expressing human RPE1 cells	[PMID: 15043407]

Chemical Information

CAS. Nr. 143901-35-3
Appearance Solid
Molecular Weight 492.52
Formel C₂₈H₂₈O₈
Color Off-white to light yellow
SMILES

O=C([C@H]([C@H]1C2=CC=CC=C2)[C@@H](O)[C@]3(O)[C@@]1(C4=CC=C(OC)C=C4)OC5=CC(OC)=CC(OC)=C35)OC
Synonyms

Aglafolin; Rocaglamide U; (-)-Methyl rocaglate
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Journal Impact Factor

Mol Cell

The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA. [Abstract]

2019 Feb 21;73(4):738-748.e9. PMID: 30595437

Lösungsmittel & Löslichkeit

In Vitro:

Ethanol : 100 mg/mL (203.04 mM; Need ultrasonic)

DMSO : 21.43 mg/mL (43.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0304 mL

10.1519 mL

20.3037 mL

5 mM

0.4061 mL

2.0304 mL

4.0607 mL

10 mM

0.2030 mL

1.0152 mL

2.0304 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.14 mg/mL (4.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.14 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.4 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 4

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.14 mg/mL (4.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.14 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.4 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ko FN, et al. PAF antagonism in vitro and in vivo by aglafoline from Aglaia elliptifolia Merr. Eur J Pharmacol. 1992 Jul 21;218(1):129-35. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	2.0304 mL	10.1519 mL	20.3037 mL	50.7594 mL
	5 mM	0.4061 mL	2.0304 mL	4.0607 mL	10.1519 mL
	10 mM	0.2030 mL	1.0152 mL	2.0304 mL	5.0759 mL
	15 mM	0.1354 mL	0.6768 mL	1.3536 mL	3.3840 mL
	20 mM	0.1015 mL	0.5076 mL	1.0152 mL	2.5380 mL
	25 mM	0.0812 mL	0.4061 mL	0.8121 mL	2.0304 mL
	30 mM	0.0677 mL	0.3384 mL	0.6768 mL	1.6920 mL
	40 mM	0.0508 mL	0.2538 mL	0.5076 mL	1.2690 mL
Ethanol	50 mM	0.0406 mL	0.2030 mL	0.4061 mL	1.0152 mL
	60 mM	0.0338 mL	0.1692 mL	0.3384 mL	0.8460 mL
	80 mM	0.0254 mL	0.1269 mL	0.2538 mL	0.6345 mL
	100 mM	0.0203 mL	0.1015 mL	0.2030 mL	0.5076 mL

Keywords

Aglafoline

1 Cited Publications

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Aglafoline

Apafant

Apafant (Standard)

Publications Citing Use of MedChemExpress (MCE) Aglafoline

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Aglafoline

Apafant

Apafant (Standard)

Publications Citing Use of MedChemExpress (MCE) Aglafoline

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Aglafoline Related Classifications

HY-19354 Related Classifications