Art. -Nr.: HY-B1205A

Atropine sulfate

(Synonyms: Tropine tropate sulfate; DL-Hyoscyamine sulfate; Sulfatropinol)

27 Cited Publications

Kundenbewertung

Based on 27 publication(s) in Google Scholar

Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia.

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Reinheit: 99.87%
CAS. Nr.: 55-48-1
Formel: C₁₇H₂₄NO₅S_0.5
Molecular Weight:338.41

Speicherung:

4°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

Atropine sulfate Chemical Structure

CAS. Nr.: 55-48-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (27)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

mAChR4

Alle mAChR Isoform-spezifische Produkte anzeigen :

In Vitro

Atropine (Tropine tropate; 1 μM; pulmonary veins and arteries) sulfate inhibits ACh-induced relaxations in human pulmonary veins^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atropine (Tropine tropate; 10 mg/kg; i.p.; once, for 40 minutes; Peromyscus sp.) sulfate inhibits the cardiac arrhythmia which normally occurs throughout torpor^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

White-footed mice (Peromyscus sp.)^[2]

Dosage:

10 mg/kg

Administration:

Intraperitoneal injection; once, for 40 minutes

Result:

Increased heart rate was a decrease in cardiac arrhythmia.

Chemical Information

CAS. Nr. 55-48-1

Appearance Solid

Molecular Weight 338.41

Formel C₁₇H₂₄NO₅S_0.5

Color White to off-white

SMILES

O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C(CO)C3=CC=CC=C3.[0.5H2SO4]

Synonyms

Tropine tropate sulfate; DL-Hyoscyamine sulfate; Sulfatropinol

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

Publications (27)

All Histological Imaging/StainingBio/Physico-chemical AssayWBIn Vivo Efficacy Study

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Journal Impact Factor

Journal Impact Factor

Most Recent

Cell

Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance. [Abstract]

2025 Nov 26;188(24):6754-6773.e29. PMID: 41138728

Cell Metab

Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies. [Abstract]

2022 Dec 6;34(12):1999-2017.e10. PMID: 36395769

Cell Stem Cell

Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems. [Abstract]

2026 May 15:S1934-5909(26)00158-X. PMID: 42143017

Neuron

Molecularly defined and functionally distinct cholinergic subnetworks. [Abstract]

2022 Nov 16;110(22):3774-3788.e7. PMID: 36130594

Kidney Int

Parasympathetic nerves in the kidney pelvis contribute to blood pressure regulation. [Abstract]

2026 Jan 19:S0085-2538(26)00008-6. PMID: 41565024

Sci Adv

EphB1-NR2B receptor signaling in glutamatergic neurons of the ventroposteromedial thalamic nucleus regulates emergence from anesthesia. [Abstract]

2025 Dec 5;11(49):eadw7972. PMID: 41348875

Cell Discov

Adenosine-independent regulation of the sleep-wake cycle by astrocyte activity. [Abstract]

2023 Feb 7;9(1):16. PMID: 36746933

Small

A Balloon Electrochemical Sensor for Conformal Interfacing With Intestinal Wall and Real-Time Monitoring of Serotonin Release. [Abstract]

2026 Jan 21:e06988. PMID: 41563114

J Hazard Mater

β-ionone inhibits the grazing of Daphnia sinensis by reducing the activity of acetylcholinesterase. [Abstract]

2024 Sep 5:479:135690. PMID: 39255669

J Hazard Mater

β-cyclocitral, a novel AChE inhibitor, contributes to the defense of Microcystis aeruginosa against Daphnia grazing. [Abstract]

2024 Mar 5:465:133248. PMID: 38147752

J Neuroinflammation

PVNOXT regulates acinar cell-mediated inflammatory response via DMVACh projections to the acinar cell. [Abstract]

2026 May 25. PMID: 42186091

Food Chem

Screening of bioactive flavour compounds targeting muscarinic-3 acetylcholine receptor from Siraitia grosvenorii and evaluation of their synergistic anti-asthmatic activity. [Abstract]

2022 Nov 30:395:133593. PMID: 35792488

J Transl Med

Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth. [Abstract]

2025 Jan 23;23(1):112. PMID: 39849539

Cell Rep

Nociceptive neurons protect cancer cells against oxidative stress. [Abstract]

2026 Mar 24;45(3):117086. PMID: 41831232

Cell Rep

Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch. [Abstract]

2022 Mar 8;38(10):110468. PMID: 35263588

J Ethnopharmacol

Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca2+ antagonism and maintaining mitochondrial function. [Abstract]

2024 Jan 30;319(Pt 2):117192. PMID: 37734472

Atropine sulfate purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]

Atropine (0.5 mg/kg; ip). Representative images of TTC-stained brain coronal sections of rats.

Atropine sulfate purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]

Atropine (0.5 mg/kg; ip). Western blot results of signal pathways.

Atropine sulfate purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]

Atropine (0.5 mg/kg; ip). Statistical results of neurological score by mNSS.

Atropine sulfate purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]

Atropine (0.5 mg/kg; ip). Statistical results of Western blot in AKT/p-AKT.

Front Pharmacol

Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway. [Abstract]

2020 Jul 31;11:1038. PMID: 32903813

Eur J Pharmacol

Activation of Piezo1 channels enhances spontaneous contractions of isolated human bladder strips via acetylcholine release from the mucosa. [Abstract]

2024 Sep 3:176954. PMID: 39237075

Atropine sulfate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Sep 3:176954. [Abstract]

Yoda1-induced ATP release was significantly attenuated in the presence of Atropine (1 μM).

Am J Physiol Renal Physiol

Anatomic and functional evidence for renal autonomic innervation in normotensive and hypertensive rats. [Abstract]

2024 Nov 1;327(5):F885-F898. PMID: 39298550

Cardiovasc Drugs Ther

Transcutaneous Auricular Vagus Nerve Stimulation Ameliorates Heart Failure with Preserved Ejection Fraction Through Regulating Macrophage Polarization Mediated by Alpha7nAChR. [Abstract]

2025 Apr 7. PMID: 40193005

Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Arch Oral Biol

Parasympathetic-macrophages-ductal epithelial cells axis promotes female rat submandibular gland regeneration after excretory duct ligation/deligation. [Abstract]

2023 Jan:145:105586. PMID: 36410162

J Biosci

M1 macrophages-derived exosomes miR-34c-5p regulates interstitial cells of Cajal through targeting SCF. [Abstract]

2021:46:90. PMID: 34544909

Can J Physiol Pharmacol

Levetiracetam induction of theta frequency oscillations in rodent hippocampus in vitro. [Abstract]

2020 Oct;98(10):725-732. PMID: 32516556

Research Square Print

2023 Feb 7.

Research Square Print

December 16th, 2022.

Research Square Preprint

2022 Mar.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (295.50 mM; Need ultrasonic)

DMSO : 62.5 mg/mL (184.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9550 mL

14.7750 mL

29.5500 mL

5 mM

0.5910 mL

2.9550 mL

5.9100 mL

10 mM

0.2955 mL

1.4775 mL

2.9550 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Konzentration Konzentration

×
Volumen Volumen

×
Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

×

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

=

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

×

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:

To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO    40% PEG300    5% Tween-80    45% Saline
Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

Protocol 2

Add each solvent one by one: 10% DMSO    90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

Protocol 3

Add each solvent one by one: 10% DMSO    90% Corn Oil
Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (295.50 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg

Animal Weight (Per Animal) Animal Weight (Per Animal)
g

Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL

Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact
MedChemExpress (MCE) .

Tel: 609-228-6898
E-mail: [email protected]
Technical Support: [email protected]

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (292 KB)

SDS (396 KB)

English - EN (396 KB)

Français - FR (396 KB)

Deutsch - DE (396 KB)

Norwegian - NO (396 KB)

Español - ES (396 KB)

Swedish - SV (396 KB)

Italian - IT (396 KB)

Korean - KR (396 KB)

Portuguese - PT (396 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

Verweise

[1]. McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33(3):373-8. [Content Brief]

[2]. Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33(2):441-57. [Content Brief]

[3]. Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. [Content Brief]

[4]. Walch L, et, al. Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130(1):73-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO / H₂O 1 mM 2.9550 mL 14.7750 mL 29.5500 mL 73.8749 mL

5 mM 0.5910 mL 2.9550 mL 5.9100 mL 14.7750 mL

10 mM 0.2955 mL 1.4775 mL 2.9550 mL 7.3875 mL

15 mM 0.1970 mL 0.9850 mL 1.9700 mL 4.9250 mL

20 mM 0.1477 mL 0.7387 mL 1.4775 mL 3.6937 mL

25 mM 0.1182 mL 0.5910 mL 1.1820 mL 2.9550 mL

30 mM 0.0985 mL 0.4925 mL 0.9850 mL 2.4625 mL

40 mM 0.0739 mL 0.3694 mL 0.7387 mL 1.8469 mL

50 mM 0.0591 mL 0.2955 mL 0.5910 mL 1.4775 mL

60 mM 0.0492 mL 0.2462 mL 0.4925 mL 1.2312 mL

80 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9234 mL

100 mM 0.0295 mL 0.1477 mL 0.2955 mL 0.7387 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Atropine sulfate Related Classifications

HY-B1205A Related Classifications

GPCR/G Protein Neuronal Signaling

mAChR

Disease Areas

Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease

Neurological Disease Cardiovascular Disease Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

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Keywords

Atropine
55-48-1
Tropine tropate
DL-Hyoscyamine
Sulfatropinol
mAChR
anti-myopia
tachyarrhythmias
Ach
pulmonary veins
bradycardia
Inhibitor
inhibitor
inhibit

Your Recently Viewed Products

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	2.9550 mL	14.7750 mL	29.5500 mL	73.8749 mL
5 mM	0.5910 mL	2.9550 mL	5.9100 mL	14.7750 mL
10 mM	0.2955 mL	1.4775 mL	2.9550 mL	7.3875 mL
15 mM	0.1970 mL	0.9850 mL	1.9700 mL	4.9250 mL
20 mM	0.1477 mL	0.7387 mL	1.4775 mL	3.6937 mL
25 mM	0.1182 mL	0.5910 mL	1.1820 mL	2.9550 mL
30 mM	0.0985 mL	0.4925 mL	0.9850 mL	2.4625 mL
40 mM	0.0739 mL	0.3694 mL	0.7387 mL	1.8469 mL
50 mM	0.0591 mL	0.2955 mL	0.5910 mL	1.4775 mL
60 mM	0.0492 mL	0.2462 mL	0.4925 mL	1.2312 mL
80 mM	0.0369 mL	0.1847 mL	0.3694 mL	0.9234 mL
100 mM	0.0295 mL	0.1477 mL	0.2955 mL	0.7387 mL

Atropine sulfate

27 Cited Publications

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Atropine sulfate

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Publications Citing Use of MedChemExpress (MCE) Atropine sulfate

Alle mAChR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (27)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table