Art. -Nr.: HY-B0892

Benzyl alcohol

(Synonyms: Benzenemethanol)

3 Cited Publications

Kundenbewertung

Based on 3 publication(s) in Google Scholar

Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated Toll-Like Receptor 4 to reduce the inflammatory response of liver injury in mice.

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Reinheit: 99.99%
CAS. Nr.: 100-51-6
Formel: C₇H₈O
Molecular Weight:108.14

Speicherung:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Benzyl alcohol Chemical Structure

CAS. Nr.: 100-51-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Microbial Metabolite

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen :

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen :

In Vitro

Benzyl alcohol (10-80 mM) regulates cyclic AMP synthesis in MDCK cells by increasing the membrane fluidity of intact renal epithelial cells^[1].
Benzyl alcohol (0-46 mM, 48 h) inhibits the hepatotoxicity of APAP by inhibiting cytochrome P450 enzyme activity in the primary liver of mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benzyl alcohol (270 mg/kg, intraperitoneal injection, 0.5-24 h) can reduce the liver injury induced by acetaminophen^[2].
Benzyl alcohol (270 mg/kg, intraperitoneal injection, 3-24 h) decreases inflammasome activation in a TLR4-dependent manner^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

APAP-induced liver injury model in mice^[2]
Dosage:

270 mg/kg
Administration:

i.p.
Result:

Attenuated the increase in ALT activities and reduced areas of necrosis at both 6 h and 24 h.
Reduced APAP metabolic activation and parameters of oxidant stress.
Reduced APAP-induced mitochondrial dysfunction.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 100-51-6
Appearance Liquid (Density: 1.045 g/cm³)
Molecular Weight 108.14
Formel C₇H₈O
Color Colorless to light yellow
SMILES

OCC1=CC=CC=C1
Synonyms

Benzenemethanol
Structure Classification
- Others
Initial Source
- Microorganisms
the white-rot fungi
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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Journal Impact Factor

Chem Sci

N-heterocyclic carbenes as clickable molecular anchors for electrochemical surface functionalization of metals and glassy carbon. [Abstract]

2025 Oct 3. PMID: 41050571
Turk J Med Sci

Benzyl alcohol improves Ang II-induced vascular and renal injury. [Abstract]

2025 Feb 19;55(2):509-517. PMID: 40342326
ChemRxiv

2025 May 9.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (924.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (924.73 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

9.2473 mL

46.2364 mL

92.4727 mL

5 mM

1.8495 mL

9.2473 mL

18.4945 mL

10 mM

0.9247 mL

4.6236 mL

9.2473 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (23.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (23.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 33.33 mg/mL (308.21 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Friedlander G, et al. Benzyl alcohol increases membrane fluidity and modulates cyclic AMP synthesis in intact renal epithelial cells. Biochim Biophys Acta. 1987 Oct 2;903(2):341-8. [Content Brief]

[2]. Du K, et al. Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. Food Chem Toxicol. 2015 Dec;86:253-61. [Content Brief]

[3]. Cai C, et al. Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice. Hepatology. 2014 Sep;60(3):990-1002. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	9.2473 mL	46.2364 mL	92.4727 mL	231.1818 mL
	5 mM	1.8495 mL	9.2473 mL	18.4945 mL	46.2364 mL
	10 mM	0.9247 mL	4.6236 mL	9.2473 mL	23.1182 mL
	15 mM	0.6165 mL	3.0824 mL	6.1648 mL	15.4121 mL
	20 mM	0.4624 mL	2.3118 mL	4.6236 mL	11.5591 mL
	25 mM	0.3699 mL	1.8495 mL	3.6989 mL	9.2473 mL
	30 mM	0.3082 mL	1.5412 mL	3.0824 mL	7.7061 mL
	40 mM	0.2312 mL	1.1559 mL	2.3118 mL	5.7795 mL
	50 mM	0.1849 mL	0.9247 mL	1.8495 mL	4.6236 mL
	60 mM	0.1541 mL	0.7706 mL	1.5412 mL	3.8530 mL
	80 mM	0.1156 mL	0.5780 mL	1.1559 mL	2.8898 mL
	100 mM	0.0925 mL	0.4624 mL	0.9247 mL	2.3118 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Benzyl alcohol

3 Cited Publications

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Benzyl alcohol

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Publications Citing Use of MedChemExpress (MCE) Benzyl alcohol

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Benzyl alcohol Related Classifications

HY-B0892 Related Classifications