Neuropathiazol
Based on 1 publication(s) in Google Scholar
Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.18%
- CAS. Nr.: 880090-88-0
- Formel: C19H18N2O2S
- Molecular Weight:338.42
-
Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
TGF-beta/Smad Compound Library
HY-L018
-
Anti-Pancreatic Cancer Compound Library
HY-L077
-
Angiogenesis-Related Compound Library
HY-L088
-
Osteogenesis Compound Library
HY-L131
-
Heterocyclic Compound Library
HY-L138
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) Neuropathiazol
More
Biologische Aktivität
Neuropathiazol (5-15 μM; 5 hours) significantly slows cell proliferation without visible cytotoxic effects[1].
Neuropathiazol (10 μM; 1-4 days) down-regulates Sox2 (a neural progenitor marker) and up-regulates NeuroD1 (a neuronal cell marker)[1].
Neuropathiazol also inhibits astroglial differentiation that is induced by LIF and BMP2[1].
Neuropathiazol induces neuronal differentiation of multipotent adult hippocampal neural progenitor cells[1].
Neuropathiazol can competitively suppress astrogliogenesis by LIF/BMP2/FBS in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HCN cells
-
Concentration:5 μM, 10 μM, 15 μM
-
Incubation Time:5 hours
-
Result:Inhibited proliferation of HCN neural progenitor cells.
-
Cell Line:HCN cells
-
Concentration:10 μM
-
Incubation Time:1 day, 4 days
-
Result:Downregulated Sox2 and upregulated NeuroD1.
Chemical Information
-
CAS. Nr. 880090-88-0
-
Appearance Solid
-
Molecular Weight 338.42
-
Formel C19H18N2O2S
-
Color Light brown to brown
-
SMILES
CN(C1=CC=C(C(OCC)=O)C=C1)C2=CSC(C3=CC=CC=C3)=N2
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Pediatr Res
Neuropathiazol induces neuronal-like differentiation in neuroblastoma cells via upregulation of PEG5. [Abstract]2025 Feb 20. PMID: 39972157
Lösungsmittel & Löslichkeit
DMSO : 33.33 mg/mL (98.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
-
Data Sheet (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9549 mL | 14.7745 mL | 29.5491 mL | 73.8727 mL |
| 5 mM | 0.5910 mL | 2.9549 mL | 5.9098 mL | 14.7745 mL | |
| 10 mM | 0.2955 mL | 1.4775 mL | 2.9549 mL | 7.3873 mL | |
| 15 mM | 0.1970 mL | 0.9850 mL | 1.9699 mL | 4.9248 mL | |
| 20 mM | 0.1477 mL | 0.7387 mL | 1.4775 mL | 3.6936 mL | |
| 25 mM | 0.1182 mL | 0.5910 mL | 1.1820 mL | 2.9549 mL | |
| 30 mM | 0.0985 mL | 0.4925 mL | 0.9850 mL | 2.4624 mL | |
| 40 mM | 0.0739 mL | 0.3694 mL | 0.7387 mL | 1.8468 mL | |
| 50 mM | 0.0591 mL | 0.2955 mL | 0.5910 mL | 1.4775 mL | |
| 60 mM | 0.0492 mL | 0.2462 mL | 0.4925 mL | 1.2312 mL | |
| 80 mM | 0.0369 mL | 0.1847 mL | 0.3694 mL | 0.9234 mL |
Neuropathiazol Related Classifications
HY-10591 Related Classifications
Powered by Bioz