Art. -Nr.: HY-N5034

Phosphorylethanolamine

(Synonyms: Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine)

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Phosphorylethanolamine (Monoaminoethyl phosphate) is a membrane phospholipid and an important precursor of Phosphatidylcholine (HY-B2233B). It is found in most animal tissues and various human extracranial tumors, playing a critical role in membrane integrity, cell division, mitochondrial respiratory function, and more. Studies have shown that changes in the abundance of Phosphorylethanolamine are associated with Alzheimer's disease and Parkinson's disease. Lowering the ratio of Phosphorylethanolamine to Phosphatidylcholine in the liver can improve insulin signaling. Phosphorylethanolamine holds promise for research in the fields of cancer, neurodegenerative disorders, and metabolic diseases.

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Reinheit: 99.90%
CAS. Nr.: 1071-23-4
Formel: C₂H₈NO₄P
Molecular Weight:141.06

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Phosphorylethanolamine Chemical Structure

CAS. Nr.: 1071-23-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Phosphorylethanolamine (Monoaminoethyl phosphate) arrests A2058 cells at the G2/M phase of the cell cycle and inhibits their proliferation, migration, and adhesion capabilities^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

A2058 cells, B16F10 cells
Concentration:

4.69-300 mM
Incubation Time:

24 h
Result:

Not only reduced viability but also blocked the capacity of A2058 cells of forming new clones.

Chemical Information

CAS. Nr. 1071-23-4
Appearance Solid
Molecular Weight 141.06
Formel C₂H₈NO₄P
Color White to off-white
SMILES

NCCOP(O)(O)=O
Synonyms

Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine
Structure Classification
- Others
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (4)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Cell Death Discov

SNORA14A inhibits hepatoblastoma cell proliferation by regulating SDHB-mediated succinate metabolism. [Abstract]

2023 Jan 30;9(1):36. PMID: 36717552
Biochem Biophys Res Commun

CircRNA circBACH1 (hsa_circ_0061395) serves as a miR-656-3p sponge to facilitate hepatocellular carcinoma progression through increasing SERBP1 expression. [Abstract]

2021 Jun 4:556:1-8. PMID: 33831787
SSRN

2025 May 22.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 125 mg/mL (886.15 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

7.0892 mL

35.4459 mL

70.8918 mL

5 mM

1.4178 mL

7.0892 mL

14.1784 mL

10 mM

0.7089 mL

3.5446 mL

7.0892 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (708.92 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Portuguese - PT (476 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kinoshita Y, et al. Phosphorylethanolamine content of human brain tumors. Neurol Med Chir (Tokyo). 1994 Dec;34(12):803-6. [Content Brief]

[2]. Hui SCN, et al. In vivo spectral editing of phosphorylethanolamine. Magn Reson Med. 2022 Jan;87(1):50-56. [Content Brief]

[3]. Calzada E,et al. Phosphatidylethanolamine Metabolism in Health and Disease. Int Rev Cell Mol Biol. 2016;321:29-88. doi: 10.1016/bs.ircmb.2015.10.001. [Content Brief]

[4]. van der Veen JN, et al. A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling. FASEB J. 2019 Apr;33(4):5045-5057. [Content Brief]

[5]. Nesic I, et al. Alterations in phosphatidylethanolamine levels affect the generation of Aβ. Aging Cell. 2012 Feb;11(1):63-72. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	7.0892 mL	35.4459 mL	70.8918 mL	177.2296 mL
	5 mM	1.4178 mL	7.0892 mL	14.1784 mL	35.4459 mL
	10 mM	0.7089 mL	3.5446 mL	7.0892 mL	17.7230 mL
	15 mM	0.4726 mL	2.3631 mL	4.7261 mL	11.8153 mL
	20 mM	0.3545 mL	1.7723 mL	3.5446 mL	8.8615 mL
	25 mM	0.2836 mL	1.4178 mL	2.8357 mL	7.0892 mL
	30 mM	0.2363 mL	1.1815 mL	2.3631 mL	5.9077 mL
	40 mM	0.1772 mL	0.8861 mL	1.7723 mL	4.4307 mL
	50 mM	0.1418 mL	0.7089 mL	1.4178 mL	3.5446 mL
	60 mM	0.1182 mL	0.5908 mL	1.1815 mL	2.9538 mL
	80 mM	0.0886 mL	0.4431 mL	0.8861 mL	2.2154 mL
	100 mM	0.0709 mL	0.3545 mL	0.7089 mL	1.7723 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Phosphorylethanolamine

4 Cited Publications

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Phosphorylethanolamine

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Publications Citing Use of MedChemExpress (MCE) Phosphorylethanolamine

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Phosphorylethanolamine Related Classifications

Art. -Nr.: HY-N5034