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Art. -Nr.: HY-102016

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SB756050

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.75%
CAS. Nr.: 447410-57-3
Formel: C₂₁H₂₈N₂O₈S₂
Molecular Weight:500.59

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

SB756050 Chemical Structure

CAS. Nr.: 447410-57-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.

In Vitro

TGR5 is a bile acid receptor and a potential target for the treatment of type 2 diabetes (T2D)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 447410-57-3
Appearance Solid
Molecular Weight 500.59
Formel C₂₁H₂₈N₂O₈S₂
Color White to off-white
SMILES

O=S(N1CCN(S(=O)(C2=CC=C(OC)C(OC)=C2)=O)CCC1)(C3=CC=C(OC)C(OC)=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Cell Death Discov

TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression. [Abstract]

2020 Jul 6:6:56. PMID: 32655894

SB756050 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2020 Jul 6:6:56. [Abstract]

GES-1 cells are treated with SB756050 (2, 5, and 10 μM) for 24 h. KLF4 and CDX2 protein expression is examined by WB. The results show that KLF4 and CDX2 expression is significantly increased.
R Soc Open Sci

Ultra-performance liquid chromatography-tandem mass spectrometric method for quantitation of the recently Food and Drug Administration approved combination of vaborbactam and meropenem in human plasma. [Abstract]

2020 Jul 8;7(7):200635. PMID: 32874656

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (99.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9976 mL

9.9882 mL

19.9764 mL

5 mM

0.3995 mL

1.9976 mL

3.9953 mL

10 mM

0.1998 mL

0.9988 mL

1.9976 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hodge RJ, et al. Safety, Pharmacokinetics, and Pharmacodynamic Effects of a Selective TGR5 Agonist, SB-756050, in Type 2 Diabetes. Clin Pharmacol Drug Dev. 2013 Jul;2(3):213-22. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9976 mL	9.9882 mL	19.9764 mL	49.9411 mL
	5 mM	0.3995 mL	1.9976 mL	3.9953 mL	9.9882 mL
	10 mM	0.1998 mL	0.9988 mL	1.9976 mL	4.9941 mL
	15 mM	0.1332 mL	0.6659 mL	1.3318 mL	3.3294 mL
	20 mM	0.0999 mL	0.4994 mL	0.9988 mL	2.4971 mL
	25 mM	0.0799 mL	0.3995 mL	0.7991 mL	1.9976 mL
	30 mM	0.0666 mL	0.3329 mL	0.6659 mL	1.6647 mL
	40 mM	0.0499 mL	0.2497 mL	0.4994 mL	1.2485 mL
	50 mM	0.0400 mL	0.1998 mL	0.3995 mL	0.9988 mL
	60 mM	0.0333 mL	0.1665 mL	0.3329 mL	0.8324 mL
	80 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6243 mL

Keywords

SB756050

2 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

1/16
1/16

SB756050 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2020 Jul 6:6:56. [Abstract]

Customer Validation
GES-1 cells are treated with SB756050 (2, 5, and 10 μM) for 24 h. KLF4 and CDX2 protein expression is examined by WB. The results show that KLF4 and CDX2 expression is significantly increased.

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SB756050

Anti-diabetic Compound Library

Orally Active Compound Library

Anti-Obesity Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Activators Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Clinical Compound Library

Publications Citing Use of MedChemExpress (MCE) SB756050

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SB756050

Anti-diabetic Compound Library

Orally Active Compound Library

Anti-Obesity Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Activators Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Clinical Compound Library

Publications Citing Use of MedChemExpress (MCE) SB756050

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SB756050 Related Classifications

HY-102016 Related Classifications