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Art. -Nr.: HY-U00162

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SZ1676

SZ1676 is a derivative of SZ1677, which is a neuromuscular blocking agent.

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CAS. Nr.: 159325-23-2
Formel: C₃₇H₅₉BrN₂O₆
Molecular Weight:707.78

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SZ1676 Chemical Structure

CAS. Nr.: 159325-23-2

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Protokoll
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SZ1676 is a derivative of SZ1677, which is a neuromuscular blocking agent.

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AChE
BChE

In Vivo

SZ1676 is the 3-acetoxy derivative^[1]. The neuromuscular (NM) effects of SZ1676 and SZ1677 are compared in beagle dogs. SZ1677 (ED₉₀=19.2±2.6 μg/kg) is 1.86 times more potent than SZ1676 (ED₉₀=35.8±2.5 μg/kg)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 159325-23-2
Molecular Weight 707.78
Formel C₃₇H₅₉BrN₂O₆
SMILES

C[C@@]12[C@](C[C@H]([N+]3(CCCC3)CC=C)[C@@H]2OC(C)=O)([H])[C@@]4([H])[C@]([C@@]5([C@@](C[C@H](OC(C)=O)[C@@H](N6CCC7(OCCO7)CC6)C5)([H])CC4)C)([H])CC1.[Br-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

Animal Administration^[2]

Dogs^[2]
Beagle dogs of about 10 kg body weight, anesthetized with isofurane are intubated and mechanically ventilated with O₂, One fore-leg is fixed above the elbow and the wrist and the ulnar nerve is stimulated at the elbow, percutaneously,with supramaximal electrical impulses of 0.2 ms duration at 0.1 or 0.4 Hz.The force of flxion of the paw (P) is quantitated and contiuously recorded, At first the ED₅₀, ED₉₀ and ED₉₅ of the 2 muscle relaxants (MR) are determined.Thirty min after maximal spontaneous recovery of P,the calculated 2×ED₉₀ is injected and the time course ol the NM and circulatory effects are determined.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. B?azewicz A, et al. Application of high-performance liquid chromatography with amperometric and coulometric detection to the analysis of SZ1677, a new neuromuscular blocking agent, and its two derivatives. J Chromatogr A. 2008 Sep 12;1204(1):114-8. [Content Brief]

[2]. Francis F. Foldes, et al. Comparison of the Neuromuscular Effects of SZ1676, SZ1677 and Vecuronium in Beagle Dogs. Muscle Relaxants pp 379-379.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Protokoll
Reinheit & Dokumentation
Verweise

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SZ1676

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