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Art. -Nr.: HY-163149

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AB-452

AB-452, a Dihydroquinolizinone (DHQ) analogue, is a potent and orally active HBV RNA destabilizer. AB-452 inhibits PAPD5/7 proteins in vitro with good in vivo efficacy in a chronic HBV mouse model.

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CAS. Nr.: 2226178-35-2
Formel: C₂₁H₂₆N₂O₆
Molecular Weight:402.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AB-452 Chemical Structure

CAS. Nr.: 2226178-35-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AB-452, a Dihydroquinolizinone (DHQ) analogue, is a potent and orally active HBV RNA destabilizer. AB-452 inhibits PAPD5/7 proteins in vitro with good in vivo efficacy in a chronic HBV mouse model^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	EC₅₀	3 nM Compound: (S)-20; AB-452	Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBeAg level measured after 16 days by ELISA Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBeAg level measured after 16 days by ELISA	[PMID: 38190324]
Hepatocyte	EC₅₀	3 nM Compound: (S)-20; AB-452	Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBsAg level measured after 16 days by ELISA Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBsAg level measured after 16 days by ELISA	[PMID: 38190324]
Hepatocyte	EC₅₀	3 nM Compound: (S)-20; AB-452	Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBV DNA level measured after 16 days by ELISA Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBV DNA level measured after 16 days by ELISA	[PMID: 38190324]
HepG2 2.2.15	CC₅₀	>50 μM Compound: (S)-20; AB-452	Cytotoxicity against human HepG2.2.15 cells by Cell-titer Glo luminescent assay Cytotoxicity against human HepG2.2.15 cells by Cell-titer Glo luminescent assay	[PMID: 38190324]
HepG2 2.2.15	EC₅₀	0.001 μM Compound: (S)-20; AB-452	Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of HBsAg level incubated for 6 days by microplate-based chemiluminescence immunoassay Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of HBsAg level incubated for 6 days by microplate-based chemiluminescence immunoassay	[PMID: 38190324]

Chemical Information

CAS. Nr. 2226178-35-2
Molecular Weight 402.44
Formel C₂₁H₂₆N₂O₆
SMILES

CC([C@H]1N2C(C3=NC(OC)=C(OCCCOC)C=C3C1)=CC(C(C(O)=O)=C2)=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Dimitar Gotchev, et al. Structure-Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer. J. Med. Chem. January 8, 2024.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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