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Art. -Nr.: HY-146039

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AChE-IN-15

AChE-IN-15 (Compound 3d) is a reversible human acetylcholinesterase (huAChE) (IC₅₀=6.8 μM) and human butyrylcholinesterase (huBChE) (IC₅₀=16.1 μM) inhibitor. AChE-IN-15 shows significant antioxidant potency, AChE-IN-15 can be used for the research of Alzheimer’s disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2242792-25-0
Formel: C₂₃H₂₄N₂O₇
Molecular Weight:440.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AChE-IN-15 Chemical Structure

CAS. Nr.: 2242792-25-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

In Vitro

AChE-IN-15 (compound 3d) inhibits huAChE and huBChE with IC₅₀ values of 6.8 and 16.1 μM and inhibits RatAChE and RatBChE with IC₅₀ values of 4.7 and 12.1μM^[1].
AChE-IN-15 (compound 3d) (25 μM) inhibits self-mediated aggregation (77.9), huAChE-induced Aβ_1-42 aggregation (73.6%), inhibit (78.9%) and disaggregate (64.6%) Cu²⁺-mediated Cu²⁺-mediated aggregation^[1].
AChE-IN-15 (compound 3d) (25 μM) is an neuroprotective agent and displays hepatoprotective activity^[1].
AChE-IN-15 (compound 3d) (25 μM) shows good blood-brain barrier (BBB) penetration^[1].
AChE-IN-15 (compound 3d) (5-10 μM) displays neuroprotective effect on Aβ_1-42-induced SH-SY5Y neurotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

PC12 cells
Concentration:

5 and 10 μM
Incubation Time:

24 hours
Result:

Increased the cell viability to 63.9% (5 μM) and 72.3% (10 μM), respectively.

In Vivo

AChE-IN-15 (compound 3d) (5-20 mg/kg; 14 days; Kunming mice) can reverse cognitive deficit.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming mice^[1]
Dosage:

5, 10 and 20 mg/kg
Administration:

for 14 days
Result:

Reversed cognitive deficit induced by scopolamine.

Chemical Information

CAS. Nr. 2242792-25-0
Molecular Weight 440.45
Formel C₂₃H₂₄N₂O₇
SMILES

O=C(OC1=CC=C(C2=CC(C3=C(O)C=C(OC(N(CC)C)=O)C=C3O2)=O)C=C1)N(CC)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhipei Sang, et al. Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease. Eur J Med Chem. 2020 Feb 1;187:111958. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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