AM12814
AM12814 is a potent and partial CB1 and CB2 agonist with Ki values of 0.7 nM and 3.4 nM. AM12814 can inhibit cAMP accumulation and recruitse β-arrestin 2. AM12814 exhibits cannabimimetic effects. AM12814 can be used for the research of neurological disease, suah as catalepsy.
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- CAS. Nr.: 3054511-18-8
- Formel: C24H38F3NO2
- Molecular Weight:429.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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rCB1-R 0.7 nM (Ki) |
hCB2-R 3.4 nM (Ki) |
AM12814 (Compound 12) binds to cannabinoid receptors with high affinity, with Ki values of 0.7 nM (rCB1) and 3.4 nM (hCB2)[1].
AM12814 (30 mins) inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in 3xHA-hCB1-CHO and 3xHA-hCB2-CHO cells with EC50 values of 8.75 nM and 22 nM[1].
AM12814 (90 mins) recruitses β-arrestin 2 in hCB1-DRx-CHO and hCB2-DRx-U2OS cells with EC50 values of 25 nM and 5.6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 mice[1]
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Dosage:0.3, 1 and 3 mg/kg
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Administration:Intraperitoneally injection
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Result:Increased immobility time in the ring test.
Reduced core body temperature.
Prolonged tail-flick latency in the hot water test.
Alleviated CFA (HY-153808)-induced mechanical hypersensitivity.
Chemical Information
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CAS. Nr. 3054511-18-8
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Molecular Weight 429.56
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Formel C24H38F3NO2
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SMILES
O=C(N[C@H](C)CO)CCC/C=C\C/C=C\C/C=C\[C@@H](C)/C=C\CCCCC(F)(F)F
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AM12814 Related Classifications
HY-178203 Related Classifications
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