AMCA
Based on 1 Customer Validation
AMCA (4-(Aminomethyl)-1-cyclohexanecarboxylic acid) is a PROTAC linker. AMCA can be used to synthesize the PROTAC molecule YB-3–17 (HY-170405).
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- Reinheit: 99.58%
- CAS. Nr.: 701-54-2
- Formel: C8H15NO2
- Molecular Weight:157.21
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | IC50 |
>2.0 × 105M
Compound: COVC-3899353050
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
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10.6019/CHEMBL4651402 |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 701-54-2
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Appearance Solid
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Molecular Weight 157.21
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Formel C8H15NO2
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Color White to light brown
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SMILES
O=C(C1CCC(CN)CC1)O
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Synonyms
4-(Aminomethyl)-1-cyclohexanecarboxylic acid
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
H2O : 87.5 mg/mL (556.58 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (265 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.3609 mL | 31.8046 mL | 63.6092 mL | 159.0230 mL |
| 5 mM | 1.2722 mL | 6.3609 mL | 12.7218 mL | 31.8046 mL | |
| 10 mM | 0.6361 mL | 3.1805 mL | 6.3609 mL | 15.9023 mL | |
| 15 mM | 0.4241 mL | 2.1203 mL | 4.2406 mL | 10.6015 mL | |
| 20 mM | 0.3180 mL | 1.5902 mL | 3.1805 mL | 7.9511 mL | |
| 25 mM | 0.2544 mL | 1.2722 mL | 2.5444 mL | 6.3609 mL | |
| 30 mM | 0.2120 mL | 1.0602 mL | 2.1203 mL | 5.3008 mL | |
| 40 mM | 0.1590 mL | 0.7951 mL | 1.5902 mL | 3.9756 mL | |
| 50 mM | 0.1272 mL | 0.6361 mL | 1.2722 mL | 3.1805 mL | |
| 60 mM | 0.1060 mL | 0.5301 mL | 1.0602 mL | 2.6504 mL | |
| 80 mM | 0.0795 mL | 0.3976 mL | 0.7951 mL | 1.9878 mL | |
| 100 mM | 0.0636 mL | 0.3180 mL | 0.6361 mL | 1.5902 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
AMCA Related Classifications
HY-A0102 Related Classifications
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