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Art. -Nr.: HY-169194

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Antimalarial agent 44

Antimalarial agent 44 (Compound 3) is an antimalarial agent against parasite. Antimalarial agent 44 has a good permeability across MDCK-MDR1 cell monolayers and a high clearance by mouse liver microsomes.

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Formel: C₃₇H₃₇N₅O₇
Molecular Weight:663.72

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antimalarial agent 44 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Parasite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	CC₅₀	>64 μM Compound: 3	Cytotoxicity against human MRC5 cells Cytotoxicity against human MRC5 cells	[PMID: 39378318]
Peritoneal macrophage	CC₅₀	>64 μM Compound: 3	Cytotoxicity against mouse Peritoneal macrophage Cytotoxicity against mouse Peritoneal macrophage	[PMID: 39378318]

In Vitro

Antimalarial agent 44 inhibits Leishmania infantum, Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense and Trypanosoma cruzi (EC₅₀: 1.8, 3, 15, 9.1, 20 μM, respectively) ^[1].
Antimalarial agent 44 (pH 7.4) has a good cell permeability across MDCK-MDR1 cell monolayers, with P_app AB of 3.5 μcm/s^[1].
Antimalarial agent 44 (pH 7.4) was efficiently cleared in mouse liver microsomes, with CL_int of >580 μL/min/mg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 663.72
Formel C₃₇H₃₇N₅O₇
SMILES

O=C(C1=CC(NC(C2=NC=CC=C2)=O)=C(C=C1)OC3=CC=C(C[C@@H]4NC(OC(C)(C)C)=O)C=C3)CNC([C@H](CC5=CC=CC=C5)NC4=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Riu, et al. Discovery of a Series of Macrocycles as Potent Inhibitors of Leishmania Infantum. Journal of medicinal chemistry, 2024, 67(20):18170-18193. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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