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Art. -Nr.: HY-189421

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Antimalarial agent-70

Antimalarial agent-70 is a C30 aminated lupane triterpenoid betulin derivative bearing a tryptamine moiety. Antimalarial agent-70 can be used for research on malaria.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₄₀H₆₂N₂O₂
Molecular Weight:602.93

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimalarial agent-70 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Antimalarial agent-70 is a C30 aminated lupane triterpenoid betulin derivative bearing a tryptamine moiety. Antimalarial agent-70 can be used for research on malaria^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HaCaT	IC50	4.2 μM	Antiproliferative activity against human HaCaT keratinocytes assessed as reduction in cell viability by dose-response assay. Antiproliferative activity against human HaCaT keratinocytes assessed as reduction in cell viability by dose-response assay.	42586491

In Vitro

Parasitic InfectionOthers

Parasitic Infection

Antimalarial agent-70 (Compound 5g) (0.25-5.0 μM) exhibits the highest antimalarial activity among the tested C30-aminated Betulin (HY-N0083) derivatives against P. falciparum 3D7, achieving 100% growth inhibition at 5.0 μM^[1].
Antimalarial agent-70 demonstrates potent antimalarial activity against both P. falciparum 3D7 (IC₅₀ = 0.628 μM) and multidrug-resistant P. falciparum Dd2 (IC₅₀ = 0.242 μM)^[1].

Others

Antimalarial agent-70 (0.0016-51 μM; 72 h) does not cause significant red blood cell lysis at concentrations up to 25 μM and only a mild hemolytic effect of 24% was observed at 51 μM^[1].
Antimalarial agent-70 exhibits moderate cytotoxicity against human keratinocytes HaCaT cells with an IC₅₀ value of 4.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 602.93
Formel C₄₀H₆₂N₂O₂
SMILES

OC[C@]12[C@@]([C@@H](CC2)[C@@H](C)CNCCC3=CNC4=C3C=CC=C4)([H])[C@]5([H])[C@]([C@]6([C@]([C@@]7([C@@](C(C)([C@H](CC7)O)C)([H])CC6)C)([H])CC5)C)(CC1)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bérubé C, et al. Synthesis and antimalarial activity of novel C30-aminated betulin derivatives. Bioorganic & medicinal chemistry letters. 2026 Aug 12;142:130760.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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