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Art. -Nr.: HY-158436

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Antitumor agent-155

Antitumor agent-155 (Compound 13) inhibits microtubule polymerization, induces autophagy and apoptosis. Antitumor agent-155 shows cytotoxicity against HCT116, A549, AGS, SK-MES-1 cells with IC₅₀s of 0.227, 0.253, 0.574, 0.423 μM respectively.

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CAS. Nr.: 3044017-96-8
Formel: C₃₀H₃₄N₂O₆
Molecular Weight:518.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Antitumor agent-155 Chemical Structure

CAS. Nr.: 3044017-96-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.253 μM Compound: 13	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 38759453]
AGS	IC₅₀	0.574 μM Compound: 13	Cytotoxicity against human AGS cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human AGS cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 38759453]
HCT-116	IC₅₀	0.227 μM Compound: 13	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 38759453]
NCM460	IC₅₀	1.09 μM Compound: 13	Cytotoxicity against human NCM460 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human NCM460 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 38759453]
SK-MES-1	IC₅₀	0.423 μM Compound: 13	Cytotoxicity against human SK-MES-1 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human SK-MES-1 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 38759453]

Chemical Information

CAS. Nr. 3044017-96-8
Molecular Weight 518.60
Formel C₃₀H₃₄N₂O₆
SMILES

COC1=CC(/C(C(N2CCN(CC2)C3=CC=C(C=C3)C)=O)=C\C4=CC(O)=C(C=C4)OC)=CC(OC)=C1OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang H, et al. Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 cells. Eur J Med Chem. 2024 Jun 5;272:116497. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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