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Art. -Nr.: HY-175567

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Apoptosis inducer 41

Apoptosis inducer 41 is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 41 exhibits remarkable inhibitory effects against MCF-7 cells (IC₅₀ = 6.2 μM). Apoptosis inducer 41 significantly arrests MCF-7 cells in the G2/M phase, increases ROS accumulation, induces mitochondrial membrane potential depolarization. Apoptosis inducer 41 can used for the study of breast cancer.

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CAS. Nr.: 3085940-57-1
Formel: C₃₉H₅₃BrN₄O₄
Molecular Weight:721.77

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Apoptosis inducer 41 Chemical Structure

CAS. Nr.: 3085940-57-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

In Vitro

Apoptosis inducer 41 (Compound 6j) (1‑100 μM, 48 h) exhibits antiproliferative activities in various cells with IC₅₀s of 7.1, 40.9, 6.2 and 46.1 against MDA-MB-231, MDA-MB-468, MCF-7 and MCF-10A cells^[1].
Apoptosis inducer 41 (1-9 μM, 24-48 h) significantly induces MCF-7 apoptosis through the mitochondrial apoptosis pathway and arrests cells in the G2/M phase^[1].
Apoptosis inducer 41 (1-9 μM, 24 h) induces ROS generation and impaires mitochondrial membrane potential (MMP)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

1, 3 and 9 nM
Incubation Time:

48 h
Result:

Observed the presence of nuclear collapse and the enhancement of red and bright blue fluorescence.
Increased the early apoptosis rates of MCF-7 cells ranged from 1.92% to 16.87%, while the late apoptosis rates ranged from 0.23% to 19.43%.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

1, 3 and 9 nM
Incubation Time:

24 h
Result:

Promoted the G2/M phase block in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

1, 3 and 9 nM
Incubation Time:

48 h
Result:

Significantly upregulated the levels of cytochrome c and cleaved caspase 8.
Increased the ratio of cleaved PARP to PARP.

Immunofluorescence^[1]

Cell Line:

MCF-7 cells
Concentration:

1, 3 and 9 nM
Incubation Time:

24 h
Result:

Increased the ROS levels by 30.67 %, 65.33 %, and 168.00 %, respectively.
Caused the MMP of MCF-7 cells depolarizes with increasing concentrations, which is characterized by a gradual decrease in the red/green fluorescence ratio.

Chemical Information

CAS. Nr. 3085940-57-1
Molecular Weight 721.77
Formel C₃₉H₅₃BrN₄O₄
SMILES

C[C@@]12[C@](C[C@@]3([H])[C@]2([H])[C@@H]([C@H](O3)CC[C@@H](C)C(NCC4=CN(N=N4)CC5=CC=C(C=C5)Br)=O)C)([H])[C@@]6([H])[C@]([C@@]7(C(C[C@H](CC7)OC(C)=O)=CC6)C)([H])CC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Huang X, et al. Synthesis and biological evaluation of diosgenin derivatives as potential anti-breast cancer agents. Bioorg Chem. 2025 Jul 26;164:108809. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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