ATX-IN-28
ATX-IN-28 is an orally active autotaxin (ATX) inhibitor with an IC50 of 13.7 nM. ATX-IN-28 downregulates the expression of pro-fibrotic α-SMA, ameliorates pathological damage of lung tissues in a bleomycin (HY-108345)-induced mouse model of pulmonary fibrosis, and reduces collagen deposition. ATX-IN-28 can be used for research related to idiopathic pulmonary fibrosis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C30H28N8O3
- Molecular Weight:548.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
ATX-IN-28 (Compound 16) exhibits excellent metabolic stability in pooled male rat liver microsomes, with a half-life of 36.16 min and an intrinsic clearance rate of 38.33 μL/min/mg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male; bleomycin-induced pulmonary fibrosis model)[1]
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Dosage:30 mg/kg; 60 mg/kg
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Administration:p.o.; once daily; 15 days
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Result:Achieved a modified Ashcroft score of 2.50 via H&E staining and 1.50 via Masson staining.
Decreased lung α-SMA expression to 37.28%.
Reduced BALF ATX activity with a relative absorbance reduction of 3.13 vs. model group, superior to positive control.
Significantly improved lung pathological injury and reduced collagen deposition.
Achieved a modified Ashcroft score of 1.50 via H&E staining and 1.50 via Masson staining.
Decreased lung α-SMA expression to 25.36%.
Mitigated body weight loss and improved survival rate compared to the model group.
Chemical Information
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Molecular Weight 548.60
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Formel C30H28N8O3
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SMILES
O=C(C1=NN(C2=CN(C(C)C)N=C2)C3=C1CCN(C4=CC=CC=C4)C3=O)NC5=CC=CC(/C=C(C#N)/C(NC)=O)=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ATX-IN-28 Related Classifications
HY-184278 Related Classifications
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