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Art. -Nr.: HY-168967

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BAY-277

BAY-277, a chemical probe, is a METAP2 degrader, with IC₅₀ values of 5.8 nM and 5.9 nM for hMETAP2 and mMETAP2, respectively.

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Formel: C₄₄H₅₂N₈O₅
Molecular Weight:772.93

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

BAY-277 Chemical Structure

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

BAY-277, a chemical probe, is a METAP2 degrader, with IC₅₀ values of 5.8 nM and 5.9 nM for hMETAP2 and mMETAP2, respectively^[1].

Alle MetAP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	DC₅₀	8.93 nM Compound: EUB0003014	Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE)) Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE))	10.6019/CHEMBL5463725
HUVEC	DC₅₀	0.2 nM Compound: EUB0003014	Degradation in HUVEC cells (WB) (Western Blot (WB)) Degradation in HUVEC cells (WB) (Western Blot (WB))	10.6019/CHEMBL5463725
HUVEC	IC₅₀	12 nM Compound: EUB0003014	2D HUVEC cells proliferation assay 2D HUVEC cells proliferation assay	10.6019/CHEMBL5463725

In Vitro

BAY-277 exhibits DC₅₀ of 8.93 nM for the degradation in HT1080 cells (CE), DC₅₀ of 0.2 nM for the degradation in HUVEC cells (WB) and IC₅₀ of 12 nM in the 2D HUVEC cells proliferation assay.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 772.93
Formel C₄₄H₅₂N₈O₅
SMILES

O=C(N1CCC(C2=CC=C3C(CN(C4C(NC(CC4)=O)=O)C3=O)=C2)CC1)CCCCCN(CC5)CCC5C6=CC=C(C=C6)OC7=NN8C(C9=C7CCCC9)=NN=C8
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Overview for BAY-277 a degrader of METAP2.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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BAY-277

Alle MetAP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

BAY-277 Related Classifications

HY-168967 Related Classifications