Art. -Nr.: HY-10588

Bay K 8644

Name: Bay K 8644
Brand: MedChemExpress
SKU: HY-10588
Price: 100.00 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: (±)-Bay K 8644)

10 Cited Publications

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Based on 10 publication(s) in Google Scholar

Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644. Bay K 8644 is a L-type Ca²⁺ channel agonist with an EC₅₀ of 17.3 nM. Bay K 8644 increases Ca²⁺ influx through sarcolemmal Ca²⁺ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects.

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Reinheit : 99.96%
CAS. Nr.: 71145-03-4
Formel: C₁₆H₁₅F₃N₂O₄
Molecular Weight:356.30

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Bay K 8644 Chemical Structure

CAS. Nr.: 71145-03-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (10)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644^[1]. Bay K 8644 is a L-type Ca²⁺ channel agonist with an EC₅₀ of 17.3 nM. Bay K 8644 increases Ca²⁺ influx through sarcolemmal Ca²⁺ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects^[2]^[3].

IC₅₀ & Target

^[2]

L-type calcium channel

17.3 nM (EC₅₀)

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	32.7 μM Compound: 57	Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influx Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influx	[PMID: 20356305]
GH3	EC₅₀	0.015 μM Compound: BAY-K-8644	Tested for 45 [Ca2+] uptake in rat pituitary growth hormone3 (GH3) cells Tested for 45 [Ca2+] uptake in rat pituitary growth hormone3 (GH3) cells	[PMID: 7692047]

In Vitro

In newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Ca²⁺ Staining Technique

Chemical Information

CAS. Nr. 71145-03-4
Appearance Solid
Molecular Weight 356.30
Formel C₁₆H₁₅F₃N₂O₄
Color Light yellow to yellow
SMILES

O=C(C1=C(C)NC(C)=C([N+]([O-])=O)C1C2=C(C(F)(F)F)C=CC=C2)OC
Synonyms

(±)-Bay K 8644
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (10)

All In Vivo Efficacy StudyBio/Physico-chemical AssayRT-PCR

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Journal Impact Factor

Phytomedicine

Unraveling the anti-primary dysmenorrhea mechanism of Ainsliaea fragrans Champ. extract by the integrative approach of network pharmacology and experimental verification. [Abstract]

2024 Jan:123:155213. PMID: 37980805

Bay K 8644 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jan:123:155213. [Abstract]

Representative physiographic recording showing AF-ext (0.25 ~ 1 mg/ml) on mice uterine strips induced by l-type Ca²⁺ channel agonist Bay K 8644 (10 μM).
Cell Death Discov

Thioredoxin system dysregulation and calpain activation drive myocardial disulfidptosis via pathological disulfide bonds remodeling. [Abstract]

2026 Jun 19. PMID: 42321161
Int J Biol Macromol

Genome-wide identification and expression analysis of neuropeptide G protein-coupled receptors in Urechis unicinctus (Annelida, Echiura). [Abstract]

2025 May;310(Pt 4):143548. PMID: 40294673

Bay K 8644 purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 May;310(Pt 4):143548. [Abstract]

Bay K 8644 (3 μM; 48 h). Settlement rate of the larvae treated with calmidazolium and Bay K 8644.

Bay K 8644 purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 May;310(Pt 4):143548. [Abstract]

Bay K 8644 (3 μM; 48 h). The relative expressions of CALM in the larvae treated with Bay K 8644 of cAMP and Ca²⁺ pathway.
Bioorg Chem

Lometrexol targets MRPL2 to suppress NSCLC via dual regulation of mitochondrial ribosomal activity and nuclear PDCD11/ Ca2+ signaling. [Abstract]

2026 Mar:170:109509. PMID: 41558196
Development

The neuropeptide FILa modulates larval settlement and ciliary function in the echiuran worm Urechis unicinctus. [Abstract]

2026 Apr 15;153(8):dev205191. PMID: 41958431
Neuroscience

TGF-β1 Protects Trauma-injured Murine Cortical Neurons by Upregulating L-type Calcium Channel Cav1.2 via the p38 Pathway. [Abstract]

2022 Jun 1;492:47-57. PMID: 35460836
Fitoterapia

2026 Mar 17.
Fitoterapia

Integrated network pharmacology and therapeutic verification of Dendrobium officinale flower on primary dysmenorrhea via inhibition of the TLR4/NF-κB/COX-2 pathway. [Abstract]

2025 Dec:187:106924. PMID: 41061996

Bay K 8644 purchased from MedChemExpress. Usage Cited in: Fitoterapia. 2025 Dec:187:106924. [Abstract]

Representative physiographic recording of uterus contractions inhibited by DOF-EA (0.25–1 mg/mL) on mice uterine strips induced by Ca²⁺ channel agonist Bay K 8644 (20 μM), with inhibition rate shown in the bar chart.

Bay K 8644 purchased from MedChemExpress. Usage Cited in: Fitoterapia. 2025 Dec:187:106924. [Abstract]

Representative physiographic recording of uterus contractions inhibited by DOF-EA (0.25–1 mg/mL) on mice uterine strips induced by Ca²⁺ channel agonist Bay K 8644 (20 μM), with inhibition rate shown in the bar chart.
Cells Dev

Small molecules induces dorsal root ganglion satellite glial cells to differentiate into sensory neuron-like cells. [Abstract]

2026 Mar:185:204073. PMID: 41690597
University of Groningen

2025 Jul 4.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 83.33 mg/mL (233.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8066 mL

14.0331 mL

28.0662 mL

5 mM

0.5613 mL

2.8066 mL

5.6132 mL

10 mM

0.2807 mL

1.4033 mL

2.8066 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.08 mg/mL (5.84 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.67 mg/mL (4.69 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. W Schreibmayer, et al. Kinetic modulation of guinea-pig cardiac L-type calcium channels by fendiline and reversal of the effects of Bay K 8644. Br J Pharmacol. 1992 May;106(1):151-6. [Content Brief]

[2]. G A Rae, et al. Interactions of calcium antagonists and the calcium channel agonist Bay K 8644 on neurotransmission of the mouse isolated vas deferens. Br J Pharmacol. 1989 Feb;96(2):333-40. [Content Brief]

[3]. H Satoh, et al. Bay K 8644 increases resting Ca2+ spark frequency in ferret ventricular myocytes independent of Ca influx: contrast with caffeine and ryanodine effects. Circ Res. 1998 Dec 14-28;83(12):1192-204. [Content Brief]

[4]. J P Gomez, et al. Effects of Bay K 8644 on L-type calcium current from newborn rat cardiomyocytes in primary culture. J Mol Cell Cardiol. 1996 Oct;28(10):2217-29. [Content Brief]

[5]. N Ives,et al. BAY k 8644, a calcium channel agonist, reverses hypotension in endotoxin-shocked rats. Eur J Pharmacol. 1986 Nov 4;130(3):169-75. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8066 mL	14.0331 mL	28.0662 mL	70.1656 mL
	5 mM	0.5613 mL	2.8066 mL	5.6132 mL	14.0331 mL
	10 mM	0.2807 mL	1.4033 mL	2.8066 mL	7.0166 mL
	15 mM	0.1871 mL	0.9355 mL	1.8711 mL	4.6777 mL
	20 mM	0.1403 mL	0.7017 mL	1.4033 mL	3.5083 mL
	25 mM	0.1123 mL	0.5613 mL	1.1226 mL	2.8066 mL
	30 mM	0.0936 mL	0.4678 mL	0.9355 mL	2.3389 mL
	40 mM	0.0702 mL	0.3508 mL	0.7017 mL	1.7541 mL
	50 mM	0.0561 mL	0.2807 mL	0.5613 mL	1.4033 mL
	60 mM	0.0468 mL	0.2339 mL	0.4678 mL	1.1694 mL
	80 mM	0.0351 mL	0.1754 mL	0.3508 mL	0.8771 mL
	100 mM	0.0281 mL	0.1403 mL	0.2807 mL	0.7017 mL

Bioz

Keywords

Bay K 8644

10 Cited Publications

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Bay K 8644

Publications Citing Use of MedChemExpress (MCE) Bay K 8644

Alle Calcium Channel Isoform-spezifische Produkte anzeigen