Bromofosfamide
Bromofosfamide is a prodrug-type alkylating agent and also an analog of Ifosfamide (HY-17419). Bromofosfamide exhibits potent in vivo anti-tumor activity against lymphoid leukemia and can be used for the research of lymphoid leukemia.
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- CAS. Nr.: 104149-14-6
- Formel: C7H15BrClN2O2P
- Molecular Weight:305.54
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Racemic bromofosfamide (50-200 mg/kg; i.p.; single dose on day 2) demonstrates potent anti-L1210 leukemia activity in male BDF1 mice, achieving 100% survival at a 200 mg/kg single i.p. dose on day 2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD2F1 (female, 10-12 weeks old, inoculated i.p. with 105 L1210 lymphoid leukemia cells on day 0)[1]
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Dosage:50 mg/kg; 60 mg/kg; 80 mg/kg; 100 mg/kg; 150 mg/kg; 200 mg/kg; 300 mg/kg; 400 mg/kg
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Administration:i.p.; single dose on day 1
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Result:Achieved 74% % ILS with 0/7 survivors on day 60 at 50 mg/kg.
Achieved 88% % ILS with 7% survivors on day 60 at 60 mg/kg.
Achieved 110% % ILS with 28% survivors on day 60 at 80 mg/kg.
Achieved > 430% or > 200% % ILS with overall 52% survivors on day 60 at 100 mg/kg.
Achieved > 550% % ILS with 70% survivors on day 60 at 150 mg/kg.
Achieved > 550% or > 600% % ILS with overall 85% survivors on day 60 at 200 mg/kg.
Achieved > 550% % ILS with 74% survivors on day 60 at 300 mg/kg.
Achieved > 500% % ILS with 67% survivors on day 60 at 400 mg/kg.
Reached an ED50 of 36 mg/kg, LD50 of 470 (453-489) mg/kg, and therapeutic index of 13.0.
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Animal Model:BDF1 (male, 6 weeks old, bearing L1210 lymphoid leukemia)[1]
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Dosage:50 mg/kg; 100 mg/kg; 200 mg/kg
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Administration:i.p.; single dose on day 2
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Result:Achieved 74% % ILS with 0/7 survivors on day 60 at 50 mg/kg.
Achieved > 200% % ILS with 1/7 survivors on day 60 at 100 mg/kg.
Achieved > 600% % ILS with 100% survivors on day 60 at 200 mg/kg.
Chemical Information
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CAS. Nr. 104149-14-6
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Molecular Weight 305.54
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Formel C7H15BrClN2O2P
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SMILES
O=P1(NCCBr)OCCCN1CCCl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Bromofosfamide Related Classifications
HY-W1057999 Related Classifications
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