Budesonide-d6
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Budesonide-d6 is deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma.
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- CAS. Nr.: 1134189-63-1
- Formel: C25H28D6O6
- Molecular Weight:436.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1134189-63-1
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Unlabeled Cas 51333-22-3
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Molecular Weight 436.57
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Formel C25H28D6O6
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SMILES
O=C1C([2H])=C[C@]2(C(C([2H])(C[C@@]3([C@@]2([C@@H](C[C@]4([C@@]3(C[C@H]5OC(O[C@]54C(C([2H])(O)[2H])=O)CCC)[H])C)O)[H])[H])[2H])=C1[2H])C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
DMSO : 215 mg/mL (492.48 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Claudia Grossmann, et al. Transactivation via the Human Glucocorticoid and Mineralocorticoid Receptor by Therapeutically Used Steroids in CV-1 Cells: A Comparison of Their Glucocorticoid and Mineralocorticoid Properties. Eur J Endocrinol. 2004 Sep;151(3):397-406. [Content Brief]
[3]. Liang Dong, et al. Intranasal Application of Budesonide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Nucleotide-Binding Oligomerization Domain-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation in Mice. J Immunol Res. 2019 Feb 27;2019:7264383. [Content Brief]
[4]. Michael A Pereira, et al. Modulation by Budesonide of DNA Methylation and mRNA Expression in Mouse Lung Tumors. Int J Cancer. 2007 Mar 1;120(5):1150-3. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2906 mL | 11.4529 mL | 22.9058 mL | 57.2646 mL |
| 5 mM | 0.4581 mL | 2.2906 mL | 4.5812 mL | 11.4529 mL | |
| 10 mM | 0.2291 mL | 1.1453 mL | 2.2906 mL | 5.7265 mL | |
| 15 mM | 0.1527 mL | 0.7635 mL | 1.5271 mL | 3.8176 mL | |
| 20 mM | 0.1145 mL | 0.5726 mL | 1.1453 mL | 2.8632 mL | |
| 25 mM | 0.0916 mL | 0.4581 mL | 0.9162 mL | 2.2906 mL | |
| 30 mM | 0.0764 mL | 0.3818 mL | 0.7635 mL | 1.9088 mL | |
| 40 mM | 0.0573 mL | 0.2863 mL | 0.5726 mL | 1.4316 mL | |
| 50 mM | 0.0458 mL | 0.2291 mL | 0.4581 mL | 1.1453 mL | |
| 60 mM | 0.0382 mL | 0.1909 mL | 0.3818 mL | 0.9544 mL | |
| 80 mM | 0.0286 mL | 0.1432 mL | 0.2863 mL | 0.7158 mL | |
| 100 mM | 0.0229 mL | 0.1145 mL | 0.2291 mL | 0.5726 mL |
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