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Cadonilimab

(Synonyms: AK104)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Cadonilimab (AK104) is a humanized tetravalent IgG1 bispecific antibody targeting PD1/CTLA4. Cadonilimab blocks both PD-1 and CTLA-4 pathways, thereby relieving their corresponding immunosuppressive effects and reversing tumor specific T cell exhaustion. Cadonilimab significantly downregulates Fc-mediated effector functions, including antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement dependent cytotoxicity (CDC). Cadonilimab can be used for research of metastatic cervical cancer, as well as other malignancies such as gastric cancer, GEJ adenocarcinoma and non-small cell lung cancer (NSCLC).

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  • Reinheit: 99.87%
  • CAS. Nr.: 2394841-59-7
  • Molecular Weight:198.64 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Cadonilimab
  • Experimental Validation Results for Cadonilimab
  • Experimental Validation Results for Cadonilimab
  • Experimental Validation Results for Cadonilimab
  • Experimental Validation Results for Cadonilimab
  • Cadonilimab Chemical Structure
    Cadonilimab Chemical Structure
CAS. Nr.: 2394841-59-7
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Assay Types
  • 1/16

    IgG1-kappa-[scFv-heavy-lambda]2

  • 1/16

    Immobilized Cadonilimab can bind Human PD-1 Protein (ECD, His Tag). The EC50 for this effect is 0.197 ng/mL.

  • 1/16

    Immobilized Cadonilimab can bind Human CTLA-4 Protein (His Tag). The EC50 for this effect is 3.07 ng/mL.

  • 1/16

    Immobilized Cadonilimab can bind Human CTLA-4 Protein (His Tag). The EC50 for this effect is 3.07 ng/mL. Flow Cytometry analysis of Raji cells labelling CTLA4 (red) with Cadonilimab (anti-CTLA4) (HY-P99117). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Flow Cytometry analysis of THP-1 cells labelling PDCD1 (red) with Cadonilimab (anti-PDCD1) (HY-P99117). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Cadonilimab Chemical Structure
    1/16
  • Cadonilimab
  • Immobilized Cadonilimab can bind Human PD-1 Protein (ECD, His Tag). The EC50 for this effect is 0.197 ng/mL.
  • Immobilized Cadonilimab can bind Human CTLA-4 Protein (His Tag). The EC50 for this effect is 3.07 ng/mL.
  • Immobilized Cadonilimab can bind Human CTLA-4 Protein (His Tag). The EC50 for this effect is 3.07 ng/mL. Flow Cytometry analysis of Raji cells labelling CTLA4 (red) with Cadonilimab (anti-CTLA4) (HY-P99117). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Flow Cytometry analysis of THP-1 cells labelling PDCD1 (red) with Cadonilimab (anti-PDCD1) (HY-P99117). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa-[scFv-heavy-lambda]2