Ceefourin 2
Based on 1 Customer Validation
Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.47%
- CAS. Nr.: 348148-51-6
- Formel: C15H9ClF3N3O2
- Molecular Weight:355.70
-
Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-10550
TariquidarP-gp Inhibitor -
HY-17384
ValspodarP-glycoprotein Inhibitor -
HY-50671
Zosuquidar trihydrochlorideP-gp Inhibitor -
HY-13646
EncequidarP-glycoprotein Inhibitor -
HY-17013
DofequidarP-glycoprotein Inhibitor -
HY-D0194
5(6)-Carboxy-2',7'-dichlorofluoresceinMRP1 Substrate -
HY-13646A
Encequidar mesylateP-gp Inhibitor -
HY-10550A
Tariquidar methanesulfonate, hydrateP-gp Inhibitor -
HY-101453
Ceefourin 1MRP4 Inhibitor -
HY-13574A
BiricodarP-glycoprotein Modulator -
HY-N2103
Tenacissoside GSrc/NF-κB Inhibitor -
HY-101511
TTT-28ABCB1 Inhibitor
Biologische Aktivität
Beschreibung
In Vitro
Ceefourin 2 is highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein; BCRP) and MRP1 (ABCC1). Ceefourin 2 has limited off-target effects and high stability[1]. Ceefourin 2 (100 nM-100 μM) has low cellular toxicity (IC50 >50 μM) in two normal (HSF, MRC5), five neuroblastoma (BE(2)-C, IMR-32, IMR-32, SK-N-SH, SHEP) and four other human cancer cell lines (HEPG2, LNCap, SJ-G2, MCF7)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 348148-51-6
-
Appearance Solid
-
Molecular Weight 355.70
-
Formel C15H9ClF3N3O2
-
Color Light yellow to brown
-
SMILES
O=C(O)C1=NN2C(C(F)(F)F)=CC(C3=CC=C(C=C3)C)=NC2=C1Cl
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 10 mg/mL (28.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8114 mL | 14.0568 mL | 28.1136 mL | 70.2839 mL |
| 5 mM | 0.5623 mL | 2.8114 mL | 5.6227 mL | 14.0568 mL | |
| 10 mM | 0.2811 mL | 1.4057 mL | 2.8114 mL | 7.0284 mL | |
| 15 mM | 0.1874 mL | 0.9371 mL | 1.8742 mL | 4.6856 mL | |
| 20 mM | 0.1406 mL | 0.7028 mL | 1.4057 mL | 3.5142 mL | |
| 25 mM | 0.1125 mL | 0.5623 mL | 1.1245 mL | 2.8114 mL |
Ceefourin 2 Related Classifications
HY-121088 Related Classifications
Powered by Bioz