Cleistanthin B
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo.
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- CAS. Nr.: 30021-77-3
- Formel: C27H26O12
- Molecular Weight:542.49
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IC50: 6.51 µM (SARS-CoV-2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
9.67 μM
Compound: 7
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Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay
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[PMID: 22119124] |
| HT-29 | IC50 |
>10 μM
Compound: 5
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Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
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[PMID: 24937209] |
| Huh-7 | CC50 |
0.784 μM
Compound: GNF-Pf-349
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NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
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[PMID: 18579783] |
| KB | IC50 |
>10 μM
Compound: 7
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Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay
Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay
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[PMID: 22119124] |
| MCF7 | IC50 |
2.44 μM
Compound: 7
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Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay
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[PMID: 22119124] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 30021-77-3
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Appearance Solid
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Molecular Weight 542.49
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Formel C27H26O12
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Color Light yellow to yellow
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SMILES
O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)=C2CO1
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Synonyms
Diphyllin O-glucoside
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9(3):471. [Content Brief]
[2]. Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6(4):383-388. [Content Brief]
[3]. Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4(2):73-7. [Content Brief]
[4]. Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5(4):109-14. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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