Conalbumin
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Conalbumin (Ovotransferrin) is an iron-binding protein present in egg white with antibacterial activity. Conalbumin can also be used to induce bronchial asthma. Conalbumin exhibits induced mRNA accumulation in chicken oviduct cells by estrogen and progesterone.
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- CAS. Nr.: 1391-06-6
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Conalbumin (0.2-100 nM; 0-6 h) can be induced in mRNA accumulation and protein synthesis in chicken oviduct explants by Estradiol (HY-B0141) and Progesterone (HY-N0437)[1].
Conalbumin (1.4-1.9 μM) chelates iron and exhibits varying degrees of growth inhibition in susceptible strains such as Micrococcus pyogenes var. albus cultured in PII/PI medium[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 mice (male, ~6 weeks old, 18-20 g, sensitized via intraperitoneal injections of conalbumin + alum, then intratracheally challenged with conalbumin)[3]
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Dosage:200 μg (sensitization); 100 μg (antigen challenge)
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Administration:i.p. (alternating weeks, with 2 mg alum in 0.3 ml PBS); intratracheal (administered 7 days after last sensitization, repeated at 20 and 30 days after initial challenge, in 50 μl PBS)
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Result:Induced typical pathological characteristics of allergic asthma in 6-week-old male CD1 mice, which is characterized by a significant increase in the percentages of peripheral blood eosinophils and basophils, a significant decrease in the percentage of monocytes, and severe peribronchial and perivascular inflammatory infiltration, epithelial edema and desquamation, as well as alveolar inflation, dilation and even emphysema in the lungs.
Chemical Information
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CAS. Nr. 1391-06-6
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Appearance Solid
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Color White to off-white
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SMILES
[Conalbumin]
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Synonyms
Ovotransferrin
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. McKnight GS. The induction of ovalbumin and conalbumin mRNA by estrogen and progesterone in chick oviduct explant cultures. Cell. 1978 Jun;14(2):403-13. [Content Brief]
[2]. FEENEY RE, et al. The antibacterial activity of the egg white protein conalbumin. J Bacteriol. 1952 Nov;64(5):629-43. [Content Brief]
[3]. El-Aidy WK, et al. Evaluation of propolis, honey, and royal jelly in amelioration of peripheral blood leukocytes and lung inflammation in mouse conalbumin-induced asthma model. Saudi J Biol Sci. 2015;22(6):780-788. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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