CX-5279
CX-5279 is an efficient and selective CK2 inhibitor with IC50 values for nCK2 and CK2α of 2.73 and 0.91 nM, respectively. CX-5279 is sensitive to mutations at Val66, Ile174, and V66I174AA, with IC50 values of 13.8, 12.5, and 23.35 nM, respectively. CX-5279's inhibitory activity against PIM1 is very weak, with a IC50 value of 8.52 μM. CX-5279 exhibits anti-proliferative activity in various cancer cell lines. CX-5279 can be used for research on cancers such as pancreatic cancer and leukemia.
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- CAS. Nr.: 1333382-32-3
- Formel: C22H15F3N5NaO2
- Molecular Weight:461.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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CK2α 0.91 nM (IC50) |
Chemical Information
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CAS. Nr. 1333382-32-3
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Molecular Weight 461.37
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Formel C22H15F3N5NaO2
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SMILES
O=C(C1=CC2=NC(NC3=CC=CC(C(F)(F)F)=C3)=C4N=C(NC5CC5)N=CC4=C2C=C1)O[Na]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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