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Art. -Nr.: HY-13027G

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DAPT (GMP)

(Synonyms: GSI-IX (GMP))

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Based on 1 Customer Validation

DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 208255-80-5
Formel: C₂₃H₂₆F₂N₂O₄
Molecular Weight:432.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DAPT (GMP) Chemical Structure

CAS. Nr.: 208255-80-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	34200 nM Compound: DAPT	Displacement of [3H]L685458 from human SPP expressed in HEK293 cells Displacement of [3H]L685458 from human SPP expressed in HEK293 cells	[PMID: 17932033]
Hep 3B2	IC₅₀	5 μM Compound: DAPT	Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 30108693]
Huh-7	IC₅₀	5 μM Compound: DAPT	Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 30108693]
Mahlavu	IC₅₀	5 μM Compound: DAPT	Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 30108693]
SNU-475	IC₅₀	0.6 μM Compound: DAPT	Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 30108693]
THP-1	IC₅₀	6.3 nM Compound: DAPT	Displacement of [3H]IN973 from gamma-secretase in human THP1 cells Displacement of [3H]IN973 from gamma-secretase in human THP1 cells	[PMID: 17932033]
THP-1	IC₅₀	>100000 nM Compound: DAPT	Displacement of [3H]L685458 from gamma-secretase in human THP1 cells Displacement of [3H]L685458 from gamma-secretase in human THP1 cells	[PMID: 17932033]

In Vitro

DAPT (GMP) (9 d) induces human induced pluripotent stem cells develop into expandable myoblasts^[1].
DAPT (GMP) (13 d) induces human pluripotent stem cells (hPSCs) develop into functional neurons^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 208255-80-5
Appearance Solid
Molecular Weight 432.46
Formel C₂₃H₂₆F₂N₂O₄
Color White to off-white
SMILES

FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
Synonyms

GSI-IX (GMP)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Choi IY, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Rep. 2016 Jun 7;15(10):2301-2312. [Content Brief]

[2]. Qi Y, et al. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017 Feb;35(2):154-163. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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