Desmethyl Bosentan
Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.
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- CAS. Nr.: 253688-61-8
- Formel: C26H27N5O6S
- Molecular Weight:537.59
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-W028393
Indole-3-pyruvic acidAHR Agonist -
HY-W028393R
Indole-3-pyruvic acid (Standard)Reference Standard -
HY-A0013
BosentanET-1 Inhibtior -
HY-W013378
Carbamazepine 10,11-epoxideCarbamazepine Metabolite -
HY-113239
HydroxycotinineNicotine Metabolite -
HY-118774
Propofol β-D-glucuronideMetabolite -
HY-133116
4-HydroxyatomoxetineNoradrenalin Re-uptake Inhibitor -
HY-124087
(±)-2-Propyl-4-pentenoic acidValproic Acid Metabolite -
HY-113093S
Ethyl glucuronide-d5Stable Isotope -
HY-W013378R
Carbamazepine 10,11-epoxide (Standard)Active Metabolite -
HY-Z8033
N-Desmethyl diltiazem hydrochlorideCYP3A7 Substrate -
HY-131527R
Wy-45494 hydrochloride (Standard)
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Sf9 | IC50 |
26 μM
Compound: 9
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Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
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[PMID: 27321813] |
Chemical Information
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CAS. Nr. 253688-61-8
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Molecular Weight 537.59
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Formel C26H27N5O6S
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SMILES
O=S(NC1=C(OC2=C(O)C=CC=C2)C(OCCO)=NC(C3=NC=CC=N3)=N1)(C4=CC=C(C(C)(C)C)C=C4)=O
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Synonyms
Ro 47-8634
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Desmethyl Bosentan Related Classifications
HY-145516 Related Classifications
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