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Art. -Nr.: HY-N3765

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Diosbulbin D

Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells.

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CAS. Nr.: 66756-57-8
Formel: C₁₉H₂₀O₆
Molecular Weight:344.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Diosbulbin D Chemical Structure

CAS. Nr.: 66756-57-8

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells^[1].

In Vitro

Diosbulbin D (10-80 μM; 12-72 h) can induce cytotoxicity in human normal liver L-02 cells^[1].
Diosbulbin D (40 μM; 24 h) induces morphological changes in L-02 cells^[1].
Diosbulbin D (20-80 μM; 12-48 h) induces L-02 cells apoptosis in a time- and concentration-dependent manner^[1].
Diosbulbin D (20-80 μM; 24 h) induces activation of caspase 3 in L-02 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

L-02 cells
Concentration:

10, 20, 40 and 80 μM
Incubation Time:

12, 24, 48 and 72 h
Result:

Decreased L-02 cells viability in a concentration- and time-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

L-02 cells
Concentration:

20, 40 and 80 μM
Incubation Time:

12, 24 and 48 h
Result:

Induced apoptosis in a time- and concentration-dependent manner.

Chemical Information

CAS. Nr. 66756-57-8
Molecular Weight 344.36
Formel C₁₉H₂₀O₆
SMILES

CC12C3C(C(CC1C(OC(C4=COC=C4)C2)=O)=O)C5CC(OC5=O)C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ma M, et al. The furano norclerodane diterpenoid disobulbin-D induces apoptosis in normal human liver L-02 cells. Exp Toxicol Pathol. 2012 Sep;64(6):611-8. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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