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Art. -Nr.: HY-187403A

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DOPE-PEG2000-PTP

Name: DOPE-PEG2000-PTP
Brand: MedChemExpress
SKU: HY-187403A
Availability: PreOrder

(Synonyms: DOPE-PEG2000-Mal-Cys-KTLLPTP)

DOPE-PEG2000-PTP (DOPE-PEG2000-Mal-Cys-KTLLPTP) is an amphiphilic lipid-PEG-peptide conjugate consisting of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the PTP (pancreatic cancer-targeting peptide). DOPE-PEG2000-PTP is used for pancreatic cancer-targeted drug delivery through liposome and nanoparticle functionalization.

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Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG2000-PTP Chemical Structure

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Biologische Aktivität

Beschreibung

In Vitro

DOPE-PEG2000-PTP: surface decoration of liposomes and lipid nanoparticles for pancreatic cancer-targeted drug delivery, enabling selective drug accumulation in pancreatic tumor tissues.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes pH-dependent membrane fusion for intracellular drug release;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces opsonization and immune clearance, and extends circulation half-life;
(3) PTP peptide; a pancreatic cancer-targeting peptide that specifically binds to receptors or surface markers overexpressed on pancreatic cancer cells, directing nanocarriers to pancreatic tumor tissues for enhanced drug uptake and improved therapeutic efficacy with reduced systemic toxicity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DOPE-PEG2000-PTP]
Synonyms

DOPE-PEG2000-Mal-Cys-KTLLPTP
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.