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Art. -Nr.: HY-126773

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Dp2mT

Dp2mT is a non-cytotoxic control compound, with an IC₅₀ of >3 μM for HIV-1 transcription inhibition and an IC₅₀ of >10 μM for cytotoxicity. Dp2mT does not bind to intracellular iron pools. Dp2mT does not inhibit CDK9 activity.

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CAS. Nr.: 741250-22-6
Formel: C₁₃H₁₃N₅S
Molecular Weight:271.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dp2mT Chemical Structure

CAS. Nr.: 741250-22-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Dp2mT (24 h) has the IC₅₀ >3 μM against HIV-1 transcription in CEM-GFP cells^[1].
Dp2mT (24 h) shows no cytotoxicity in CEM T cells, with an IC₅₀ >10 μM^[1].
Dp2mT (10 μM; 24 h) does not inhibit CDK9 kinase activity in 293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

CEM T cells
Concentration:

/
Incubation Time:

24 h
Result:

Showed no cytotoxicity to CEM T cells after 24 h of incubation, with an IC₅₀ greater than 10 μM.

Related Protocols :

Chemical Information

CAS. Nr. 741250-22-6
Molecular Weight 271.34
Formel C₁₃H₁₃N₅S
SMILES

S=C(N)N(N=C(C1=NC=CC=C1)C2=NC=CC=C2)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Debebe Z, et al. Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9. Mol Pharmacol. 2011;79(1):185-196. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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