DSPE-PEG-Folate, MW 3350
Based on 1 Customer Validation
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.41%
- CAS. Nr.: 1236288-25-7
- Formel: C65H114N11O16P
- Molecular Weight:3400 (Average)
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Biologische Aktivität
Beschreibung
In Vitro
Nanoparticles constructed with DSPE-PEG-Folate and anticancer drugs enter cells mainly through the endocytosis pathway mediated by FA receptors. The nanoparticles mainly accumulate in the cytoplasm, while the released drugs are distributed in the cytoplasm and nucleus, which can effectively deliver drugs to the nucleus to play a role. DSPE-PEG-Folate can increase the elimination half-life of the drug and prolong the blood circulation time[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1236288-25-7
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Appearance Solid
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Molecular Weight 3400 (Average)
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Formel C65H114N11O16P
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Color Yellow to brown
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SMILES
O=C(NCCOP(O)(OCC(COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCNC(CCC(C(O)=O)NC(C1=CC=C(NCC(N=C23)=CNC3=NC(N)=NC2=O)C=C1)=O)=O.N.N.[n]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Li Y, et, al. Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release. ACS Appl Mater Interfaces. 2015 Aug 19;7(32):17573-81. [Content Brief]
[2]. Werner ME, et, al. Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. Biomaterials. 2011 Nov;32(33):8548-54. [Content Brief]
[3]. Patlolla RR, et al. Folate-targeted etoposide-encapsulated lipid nanospheres. J Drug Target. 2008 May;16(4):269-75. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DSPE-PEG-Folate, MW 3350 Related Classifications
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