Eniporide
Based on 1 publication(s) in Google Scholar
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest.
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- CAS. Nr.: 176644-21-6
- Formel: C14H16N4O3S
- Molecular Weight:320.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Eniporide
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Biologische Aktivität
ENIPORIDE is a potent Na+/H+ exchange inhibitor.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Clinically relevant pig models of cardiopulmonary bypass (CPB) and cardioplegia[1]
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Dosage:3 mg/kg
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Administration:IV; systemic infusion before cardioplegia with added 2 μM Eniporide or not
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Result:Had no effect on standard hemodynamics including vascular pressures and cardiac index nor for cardiac performance factors.
Reduced myocardial edema and improves heart function.
Chemical Information
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CAS. Nr. 176644-21-6
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Molecular Weight 320.37
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Formel C14H16N4O3S
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SMILES
CS(=O)(C1=C(N2C=CC=C2)C=C(C)C(C(NC(N)=N)=O)=C1)=O
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Synonyms
EMD-96785
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1. [Abstract]2020 Apr 2;10(1):5800. PMID: 32242030
Reinheit & Dokumentation
Verweise
[1]. Zeymer U, et al. The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol. 2001 Nov 15;38(6):1644-50. [Content Brief]
[2]. Klass O, et al. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. Ann Thorac Surg. 2004 Feb;77(2):658-63. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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