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Art. -Nr.: HY-153256

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EP3 antagonist 4

Name: EP3 antagonist 4
Brand: MedChemExpress
SKU: HY-153256
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EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a K_i value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes.

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CAS. Nr.: 2408297-80-1

Formel: C₂₂H₂₀Cl₃FN₄O₃S₂

Molecular Weight:577.91

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

EP3 antagonist 4 Chemical Structure

CAS. Nr.: 2408297-80-1

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Data Download

Data Sheet (281 KB)

Handling Instructions (2659 KB)

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Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec

Biologische Aktivität

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen
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DP

EP

FP

IP

TXA₂/TP

TXB₂

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Bioz

Biologische Aktivität

Beschreibung

EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a K_i value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes^[1].

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen :

DP

EP

FP

IP

TXA₂/TP

TXB₂

Chemical Information

CAS. Nr. 2408297-80-1

Molecular Weight 577.91

Formel C₂₂H₂₀Cl₃FN₄O₃S₂

SMILES

O=S(NC(NC/C(F)=C1CCCC(C=N2)=C\1N2CC3=C(C=C(C=C3)Cl)Cl)=O)(C4=CC(C)=C(S4)Cl)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Zhu B, et al. Discovery and Optimization of 7-Alkylidenyltetrahydroindazole-Based Acylsulfonamide EP3 Antagonists. ACS Med Chem Lett. 2021 Dec 7;13(1):111-117. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Konzentration Konzentration

×
Volumen Volumen

×
Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

×

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

=

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

×

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

EP3 antagonist 4 Related Classifications

HY-153256 Related Classifications

GPCR/G Protein

Prostaglandin Receptor

Disease Areas

Metabolic or Endocrine Disease

Metabolic Disease

Bioz

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Keywords

EP3 antagonist 4
2408297-80-1
Prostaglandin Receptor
diabetes
beta cell
dysfunction
rat
Inhibitor
inhibitor
inhibit

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