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Art. -Nr.: HY-181040

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Factor B-IN-8

Factor B-IN-8 (Compound (3R ,4R )-15) is a potent, selective and orally active factor B inhibitor with an IC₅₀ of 10.2 nM. Factor B-IN-8 can effectively inhibit the binding of factor B to C3b and the subsequent formation of C3 convertase (C3bBb). Factor B-IN-8 can inhibit the deposition of membrane attack complex (MAC) mediated by alternativepathway with an IC₅₀ of 59.3 nM. Factor B-IN-8 can reduce the cleavage of factor B protein and decrease the deposition of complement C3d in the glomeruli and renal tubules. Factor B-IN-8 can be used for researches of arthritis and paroxysmal nocturnal hemoglobinuria (PNH).

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CAS. Nr.: 3049710-19-9
Formel: C₂₄H₂₅F₃N₂O₄
Molecular Weight:462.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Factor B-IN-8 Chemical Structure

CAS. Nr.: 3049710-19-9

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Biologische Aktivität
- Beschreibung
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	AUC_0-t	AUC_0-∞	V_ss	T_max	F
Dog^[1]	3 mg/kg	i.v.	3.16 h	14947 ng/mL	8333 ng·h/mL	9487 ng·h/mL	1.23 L/kg	/	/
Dog^[1]	6 mg/kg	i.g.	5.83 h	4680 ng/mL	14388 ng·h/mL	16738 ng·h/mL	/	0.46 h	86.77 %
Rat^[1]	10 mg/kg	i.v.	10.58 h	16788 ng/mL	11413 ng·h/mL	15313 ng·h/mL	9.18 L/kg	/	/
Rat^[1]	20 mg/kg	i.g.	9.28 h	2659 ng/mL	8793 ng·h/mL	13505 ng·h/mL	/	0.38 h	51.82 %

Chemical Information

CAS. Nr. 3049710-19-9
Molecular Weight 462.46
Formel C₂₄H₂₅F₃N₂O₄
SMILES

CC(C=C1OC)=C(NC=C2)C2=C1O[C@H]3[C@H](C4=CC=C(C=C4)C(O)=O)CN(CC3)CC(F)(F)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ma C, et al. Discovery of (3R,4R)-15: An Advanced Factor B Inhibitor Entering Phase 3 for Complement-Mediated Diseases. J Med Chem. 2026 Jan 22;69(2):867-894. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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